Relationship between acute morphine and the course of PTSD in children with burns
Relationship between acute morphine and the course of PTSD in children with burns
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DOI：
10.1097/00004583-200108000-00013
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发表时间：
2001-08-01
影响因子：
13.3
通讯作者：
King, L
中科院分区：
文献类型：
--
作者：
Saxe, G;Stoddard, F;King, L
目标：探讨急性烧伤住院治疗期间吗啡剂量与出院后6个月内创伤后应激障碍（PTSD）症状病程之间的关系。方法：24名因急性烧伤入院的儿童接受了两次儿童创伤后应激障碍反应指数评估：在医院和出院后6个月。住院期间还进行了彩色疼痛量表评分。所有患者在住院期间均接受吗啡治疗。通过图表审查计算每例受试者的吗啡平均剂量（mg/kg/天）。结果如下：皮尔逊积矩相关性揭示了在医院接受的吗啡剂量与PTSD症状减少8个月之间的显着相关性。接受更高剂量吗啡的儿童在6个月内PTSD症状的减少更大。结论：本研究表明，急性吗啡治疗可以间接预防PTSD。这一结果进行了讨论的条件反射恐惧和巩固的创伤记忆的吗啡的可能影响。
Objective: To investigate the relationship between the dose of morphine administered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period following discharge from the hospital. Method: Twenty-four children admitted to the hospital for an acute burn were assessed twice with the Child PTSD Reaction Index: while in the hospital and 6 months after discharge. The Colored Analogue Pain Scale was also administered during the hospitalization. All patients received morphine while in the hospital. The mean dose of morphine (mg/kg/day) was calculated for each subject through chart review. Results: The Pearson product moment correlation revealed a significant association between the dose of morphine received while in the hospital and a 8-month reduction in PTSD symptoms. Children receiving higher doses of morphine had a greater reduction in PTSD symptoms over 6 months. Conclusions: This study suggests the possibility that acute treatment with morphine can secondarily prevent PTSD. This result is discussed in terms of the possible effect of morphine on fear conditioning and the consolidation of traumatic memory.