Transcription factors and drug resistance
Transcription factors and drug resistance
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DOI：
10.1016/j.ejca.2005.08.007
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发表时间：
2005-11-01
影响因子：
8.4
通讯作者：
Izumi, H
中科院分区：
文献类型：
--
作者：
Kohno, K;Uchiumi, T;Izumi, H
对抗癌药物的内在或获得性耐药是化疗成功的主要障碍。已知抗癌药物可以调节信号转导途径并改变在耐药性中起重要作用的基因表达。新出现的证据表明，基因组对抗癌药物反应的复杂性源于多种转录因子的精细基因表达。在这里，我们简要地描述了实体瘤的发展和耐药细胞的出现。我们还回顾了已知的转录因子与药物耐药，特别是顺铂耐药有关。(c) 2005 Elsevier Ltd版权所有。
Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance. Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors. Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin. (c) 2005 Elsevier Ltd. All rights reserved.