A major QTL controls susceptibility to spinal curvature in the curveback guppy.
A major QTL controls susceptibility to spinal curvature in the curveback guppy.
复制标题
DOI：
10.1186/1471-2156-12-16
复制
发表时间：
2011-01-26
期刊：
影响因子：
2.9
通讯作者：
Breden F
中科院分区：
文献类型：
--
作者：
Gorman KF;Christians JK;Parent J;Ahmadi R;Weigel D;Dreyer C;Breden F
了解可遗传脊柱弯曲的遗传基础将有利于医学和水产养殖。在其他健康儿童中，遗传性脊柱弯曲（即特发性脊柱侧凸和Scheuermann脊柱后凸）占所有脊柱弯曲的80%以上，并且通过支撑、住院、手术和慢性背痛带来了大量的医疗费用。在水产养殖中，遗传性脊柱弯曲的患病率可高达种群的80%，因此通过生产损失造成了巨大的成本。可遗传性脊柱弯曲的遗传基础尚不清楚，因此本研究的目的是确定影响曲背孔比鱼可遗传性脊柱弯曲的数量性状位点。先前的研究表明，驼背与人类特发性脊柱侧凸的表型相似，表明这种畸形有共同的生物学途径。在LG 14的初始定位杂交中检测到一个以隐性方式起作用并解释曲线敏感性的主要效应QTL。在第二个杂交中，我们确认了这一易感性位点，并将其精细定位到一个5厘米的区域，该区域解释了总表型方差的82.6%。我们确定了一个控制曲率敏感性的主要QTL。该位点包含超过100个基因，包括MTNR1B，一个人类特发性脊柱侧凸的候选基因。与曲背孔目鱼的可遗传脊柱弯曲相关的基因的鉴定有可能阐明人类和经济上重要的硬骨鱼脊柱弯曲的生物学基础。
Understanding the genetic basis of heritable spinal curvature would benefit medicine and aquaculture. Heritable spinal curvature among otherwise healthy children (i.e. Idiopathic Scoliosis and Scheuermann kyphosis) accounts for more than 80% of all spinal curvatures and imposes a substantial healthcare cost through bracing, hospitalizations, surgery, and chronic back pain. In aquaculture, the prevalence of heritable spinal curvature can reach as high as 80% of a stock, and thus imposes a substantial cost through production losses. The genetic basis of heritable spinal curvature is unknown and so the objective of this work is to identify quantitative trait loci (QTL) affecting heritable spinal curvature in the curveback guppy. Prior work with curveback has demonstrated phenotypic parallels to human idiopathic-type scoliosis, suggesting shared biological pathways for the deformity. A major effect QTL that acts in a recessive manner and accounts for curve susceptibility was detected in an initial mapping cross on LG 14. In a second cross, we confirmed this susceptibility locus and fine mapped it to a 5 cM region that explains 82.6% of the total phenotypic variance. We identify a major QTL that controls susceptibility to curvature. This locus contains over 100 genes, including MTNR1B, a candidate gene for human idiopathic scoliosis. The identification of genes associated with heritable spinal curvature in the curveback guppy has the potential to elucidate the biological basis of spinal curvature among humans and economically important teleosts.
登录
查看更多内容
DOI：
10.1186/1748-7161-1-2
发表时间：
2006-03-31
期刊：
Scoliosis
影响因子：
--
作者：
Asher MA;Burton DC
通讯作者：
Burton DC
影响因子：
4.5
作者：
Koumoundouros, G;Maingot, E;Kentouri, M
通讯作者：
Kentouri, M
DOI：
10.1302/0301-620x.67b2.3980523
发表时间：
1985-01-01
影响因子：
--
作者：
DEACON, P;BERKIN, CR;DICKSON, RA
通讯作者：
DICKSON, RA
影响因子：
3
作者：
Qiu, Xu Sheng;Tang, Nelson L. S.;Cheng, Jack C. Y.
通讯作者：
Cheng, Jack C. Y.
影响因子：
2
作者：
Miller, NH;Marosy, B;Wilson, AF
通讯作者：
Wilson, AF