Chronic cough due to nonasthmatic eosinophilic bronchitis - ACCP evidence-based clinical practice guidelines
Chronic cough due to nonasthmatic eosinophilic bronchitis - ACCP evidence-based clinical practice guidelines
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DOI：
10.1378/chest.129.1_suppl.116s
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发表时间：
2006-01-01
期刊：
影响因子：
9.6
通讯作者：
Brightling, CE
中科院分区：
文献类型：
--
作者：
Brightling, CE
目的：非哮喘性嗜酸粒细胞性支气管炎是一种新认识的慢性咳嗽的病因。我们的目的是审查的发病机制，自然史，诊断和治疗这种condition.Methods：目前的文献进行了审查，使用奥维德MEDLINE和PubMed文献综述的所有研究发表在英语1963年至2004年12月使用的医学主题词“嗜酸性支气管炎。结果：非哮喘性嗜酸细胞性支气管炎是慢性咳嗽的常见原因。其特征在于存在嗜酸性气道炎症，类似于在哮喘中所见。然而，与哮喘相反，非哮喘性嗜酸粒细胞性支气管炎与可变气流限制或气道高反应性无关。功能相关性的差异与气道壁内肥大细胞定位的差异有关，哮喘患者发生气道平滑肌浸润，非哮喘性嗜酸性支气管炎患者发生上皮浸润。诊断是通过临床、放射学和肺功能评估排除慢性咳嗽的其他原因后，通常通过诱导痰分析确认嗜酸性气道炎症。咳嗽通常对吸入皮质类固醇治疗反应良好。治疗的剂量和持续时间因患者而异。这种情况可以是短暂的，发作性的，或持续的，除非治疗，偶尔患者可能需要长期的泼尼松treatment.Conclusions：进一步研究这种情况下，可能会提高我们的理解，气道炎症和气道反应性，导致新的治疗药物的目标，用于治疗哮喘和非哮喘性嗜酸性支气管炎。
Objectives: Nonasthmatic eosinophilic bronchitis is a newly recognized cause of chronic cough. Our objective was to review the pathogenesis, natural history, diagnosis, and treatment of this condition.Methods: The current literature was reviewed using an Ovid MEDLINE and PubMed literature review for all studies published in the English language from 1963 to December 2004 using the medical subject heading term "eosinophilic bronchitis."Results: Nonasthmatic eosinophilic bronchitis is a common cause of chronic cough. it is characterized by the presence of eosinophilic airway inflammation, similar to that seen in asthma. However, in contrast to asthma, nonasthmatic eosinophilic bronchitis is not associated with variable airflow limitation or airway hyperresponsiveness. The differences in functional association are related to differences in the localization of mast cells within the airway wall, with airway smooth muscle infiltration occurring in patients with asthma, and epithelial infiltration in patients with nonasthmatic eosinophilic bronchitis. Diagnosis is made by the confirmation of eosinophilic airway inflammation usually with induced sputum analysis after the exclusion of other causes for chronic cough on clinical, radiologic, and lung function assessment. The cough usually responds well to treatment with inhaled corticosteroids. The dose and duration of treatment differ between patients. The condition can be transient, episodic, or persistent unless treated, and occasionally patients may require long-term prednisone treatment.Conclusions: Further study of this condition may improve our understanding of airway inflammation and airway responsiveness, leading to novel targets for therapeutic agents for the treatment of both asthma and nonasthmatic eosinophilic bronchitis.