HDL and cognition in neurodegenerative disorders.
HDL and cognition in neurodegenerative disorders.
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DOI：
10.1016/j.nbd.2014.07.015
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发表时间：
2014-12
影响因子：
6.1
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Hottman DA;Chernick D;Cheng S;Wang Z;Li L
高密度脂蛋白（HDL）是由多种脂质和蛋白质组成的一组异质性脂蛋白。HDL在体循环和大脑中形成。除了是胆固醇逆向转运途径中的关键参与者之外，HDL还具有广泛的其他功能，包括抗氧化、抗炎、促内皮功能、抗血栓形成和调节免疫功能。已经确定高血浆HDL水平可以预防心血管疾病。越来越多的证据表明，HDL的有益作用延伸到许多其他系统，包括中枢神经系统。认知是一种复杂的大脑功能，包括感知，思维和记忆的所有方面。认知功能通常在衰老过程中下降，并且这种下降表现为年龄相关的和进行性神经退行性疾病如阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症中的认知障碍/痴呆。越来越令人担忧的是，目前没有有效的治疗方法来预防或治疗这些毁灭性的疾病。新出现的证据表明，HDL可能在正常和病理条件下保护认知功能方面发挥关键作用。这篇综述试图总结最近的遗传，临床和实验证据HDL对认知的影响，在老化和神经退行性疾病，以及潜在的HDL增强方法，以改善认知功能。
High-density lipoproteins (HDL) are a heterogeneous group of lipoproteins composed of various lipids and proteins. HDL is formed both in the systemic circulation and in the brain. In addition to being a crucial player in the reverse cholesterol transport pathway, HDL possesses a wide range of other functions including anti-oxidation, anti-inflammation, pro-endothelial function, anti-thrombosis, and modulation of immune function. It has been firmly established that high plasma levels of HDL protect against cardiovascular disease. Accumulating evidence indicates that the beneficial role of HDL extends to many other systems including the central nervous system. Cognition is a complex brain function that includes all aspects of perception, thought, and memory. Cognitive function often declines during aging and this decline manifests as cognitive impairment/dementia in age-related and progressive neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. A growing concern is that no effective therapy is currently available to prevent or treat these devastating diseases. Emerging evidence suggests that HDL may play a pivotal role in preserving cognitive function under normal and pathological conditions. This review attempts to summarize recent genetic, clinical and experimental evidence for the impact of HDL on cognition in aging and in neurodegenerative disorders as well as the potential of HDL-enhancing approaches to improve cognitive function.
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影响因子：
9.8
作者：
Atzmon, Gil;Rincon, Marielisa;Schechter, Clyde B;Shuldiner, Alan R;Lipton, Richard B;Bergman, Aviv;Barzilai, Nir
通讯作者：
Barzilai, Nir
DOI：
10.1046/j.1365-2710.2003.00463.x
发表时间：
2003-02-01
影响因子：
2
作者：
Akhondzadeh, S;Noroozian, M;Khani, M
通讯作者：
Khani, M
影响因子：
6.5
作者：
Buga, Georgette M.;Frank, Joy S.;Fogelman, Alan M.
通讯作者：
Fogelman, Alan M.
影响因子：
9.9
作者：
Barzilai, N.;Atzmon, G.;Lipton, R. B.
通讯作者：
Lipton, R. B.
影响因子：
15.9
作者：
Brunham, LR;Kruit, JK;Hayden, MR
通讯作者：
Hayden, MR