Association of total and free testosterone with cardiovascular disease in a nationally representative sample of white, black, and Mexican American men.
Association of total and free testosterone with cardiovascular disease in a nationally representative sample of white, black, and Mexican American men.
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在白人、黑人和墨西哥裔美国男性的全国代表性样本中，总睾酮和游离睾酮与心血管疾病的关系。
DOI：
10.1038/s41443-022-00660-7
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发表时间：
2022
影响因子：
2.6
通讯作者：
Tsilidis,KonstantinosK
中科院分区：
文献类型：
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作者：
Lopez,DavidS;Taha,Shaden;Gutierrez,Sirena;Villasante-Tezanos,Alejandro;Khalife,WissamI;Alzweri,Laith;Markides,Kyriakos;Baillargeon,Jacques;Tsilidis,KonstantinosK
总睾酮(T)和计算的游离睾酮(T)与心血管疾病(CVD)之间的关系尚不清楚。特别是在具有全国代表性的男性样本中，这些关联根据种族和族裔的不同而变化。数据包括来自NHANES的7,058名男性(≥20岁)。心血管疾病被定义为任何已报道的心力衰竭(HF)、冠状动脉疾病(CAD)、心肌梗死(MI)和中风的诊断。对参加晨检的男性进行总T(ng/m L)测定。采用加权多变量调整后的Logistic回归模型。我们发现低T(OR = 1.57，95%CI = 1.17~2.11)、低计算游离T(OR = 1.53，95%CI = 1.10~2.17)、总T(Q1vs Q5)、计算游离T(Q1vs Q5)与心血管疾病相关。在疾病特异性分析中，低T增加心肌梗死(OR = 1.72，95%CI = 1.08~2.75)和心力衰竭(OR = 1.74，95%CI = 1.08~2.82)的患病率，但总T的持续增加降低了冠心病的患病率。在白人和墨西哥裔美国人中也发现了类似的反向关联，但黑人没有(OR = 0.93，95%CI = 0.49-1.76)。低T水平和计算的游离T水平与总体心血管疾病以及在白人和墨西哥裔美国人中的患病率增加有关。在总体人群中，与具体的心血管疾病结果的相关性仍然是相同的。
Associations of total testosterone (T) and calculated free T with cardiovascular disease (CVD) remain poorly understood. Particularly how these associations vary according to race and ethnicity in a nationally representative sample of men. Data included 7058 men (≥20 years) from NHANES. CVD was defined as any reported diagnosis of heart failure (HF), coronary artery disease (CAD), myocardial infarction (MI), and stroke. Total T (ng/mL) was obtained among males who participated in the morning examination. Weighted multivariable-adjusted logistic regression models were conducted. We found associations of low T (OR = 1.57, 95% CI = 1.17–2.11), low calculated free T (OR = 1.53, 95% CI = 1.10–2.17), total T (Q1vs Q5), and calculated free T (Q1vs Q5) with CVD after adjusting for estradiol and SHBG. In disease specific analysis, low T increased prevalence of MI (OR = 1.72, 95% CI = 1.08–2.75) and HF (OR = 1.74, 95% CI = 1.08–2.82), but a continuous increment of total T reduced the prevalence of CAD. Similar inverse associations were identified among White and Mexican Americans, but not Blacks (OR = 0.93, 95% CI = 0.49–1.76). Low levels of T and calculated free T were associated with an increased prevalence of overall CVD and among White and Mexican Americans. Associations remained in the same direction with specific CVD outcomes in the overall population.