Phylogenetic Relationship of Necoclí Virus to Other South American Hantaviruses (Bunyaviridae: Hantavirus).
Phylogenetic Relationship of Necoclí Virus to Other South American Hantaviruses (Bunyaviridae: Hantavirus).
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Necoclí 病毒与其他南美汉坦病毒的系统发育关系（布尼亚病毒科：汉坦病毒）。
DOI：
10.1089/vbz.2014.1739
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fulhorst,CharlesF
中科院分区：
文献类型：
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作者：
Montoya-Ruiz,Carolina;Cajimat,MariaNB;Milazzo,MaryLouise;Diaz,FranciscoJ;Rodas,JuanDavid;Valbuena,Gustavo;Fulhorst,CharlesF
先前的研究结果表明，Cherrie的甘蔗鼠（Zygodontomys cherriei）是哥伦比亚Necoclí病毒（布尼亚病毒科，汉坦病毒属）的主要宿主。在这项研究中，对完整的核衣壳蛋白基因序列和完整的糖蛋白前体基因序列的贝叶斯分析证实，Necoclí病毒与Maporal病毒在遗传学上密切相关，后者主要与委内瑞拉西部的脆弱侏儒稻鼠（Oligoryzomys delicatus）有关。在成对比较中，Necocli病毒核衣壳蛋白的完整氨基酸序列与其他汉坦病毒核衣壳蛋白的完整氨基酸序列之间的非同一性≥ 8.7%。同样，Necoclí病毒糖蛋白前体的完整氨基酸序列与其他汉坦病毒糖蛋白前体的完整氨基酸序列之间的非同一性≥ 11.7%。总的来说，Necoclí病毒与Z. Cherrieiin Colombia的研究结果、完整的核衣壳蛋白基因序列和完整的糖蛋白前体基因序列的贝叶斯分析结果以及氨基酸序列的成对比较结果强烈支持Necocli病毒代表汉坦病毒属中的一个新种的观点。巴拿马的短尾病毒（brevicauda cherriein Panama）和Necoclí病毒是同种的。
The results of a previous study suggested that Cherrie's cane rat (Zygodontomys cherriei) is the principal host of Necoclí virus (familyBunyaviridae, genusHantavirus) in Colombia. Bayesian analyses of complete nucleocapsid protein gene sequences and complete glycoprotein precursor gene sequences in this study confirmed that Necoclí virus is phylogenetically closely related to Maporal virus, which is principally associated with the delicate pygmy rice rat (Oligoryzomys delicatus) in western Venezuela. In pairwise comparisons, nonidentities between the complete amino acid sequence of the nucleocapsid protein of Necoclí virus and the complete amino acid sequences of the nucleocapsid proteins of other hantaviruses were ≥8.7%. Likewise, nonidentities between the complete amino acid sequence of the glycoprotein precursor of Necoclí virus and the complete amino acid sequences of the glycoprotein precursors of other hantaviruses were ≥11.7%. Collectively, the unique association of Necoclí virus withZ. cherrieiin Colombia, results of the Bayesian analyses of complete nucleocapsid protein gene sequences and complete glycoprotein precursor gene sequences, and results of the pairwise comparisons of amino acid sequences strongly support the notion that Necoclí virus represents a novel species in the genusHantavirus.Further work is needed to determine whether Calabazo virus (a hantavirus associated withZ. brevicauda cherrieiin Panama) and Necoclí virus are conspecific.