Continuous positive airway pressure for treatment of obstructive sleep apnea in stroke survivors: what do we really know?
Continuous positive airway pressure for treatment of obstructive sleep apnea in stroke survivors: what do we really know?
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DOI：
10.1161/strokeaha.112.666248
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发表时间：
2012-11
期刊：
影响因子：
8.3
通讯作者：
Dimsdale JE
中科院分区：
文献类型：
--
作者：
Tomfohr LM;Hemmen T;Natarajan L;Ancoli-Israel S;Loredo JS;Heaton RK;Bardwell W;Mills PJ;Lee RR;Dimsdale JE
招募进入随机研究似乎特别具有挑战性；调查人员报告说，对数百名潜在参与者进行了筛选，但入选比例相对较低。在被考虑纳入随机对照试验的参与者中，70%至少有一项排除标准。20-22，26，27当被问及时，55%的没有排除标准的患者拒绝参与。20-22、26、27名参与者被随机分配到CPAP干预组，其中可获得坚持数据的参与者(N=165)，分配到CPAP组的人中有48%在最后评估点被遵守(仅限在线数据补充表II和III)。随机研究的持续时间为1至3个月，接受筛查并可进行随访的参与者的总百分比通常为4%至13%。20-24岁，在RCT研究中筛选的3473名参与者中，26名在上一次评估点只有2.3%的人遵守CPAP(图)。该图说明了隔离符合条件、愿意参与研究并符合此类治疗研究的严格要求的患者群体所面临的困难。
Recruitment into randomized studies appeared particularly challenging; investigators reported screening hundreds of potential participants but enrolling relatively low percentages. Of participants who were considered for inclusion into an RCT, 70% had at least one exclusionary criteria. 20–22, 26, 27 When approached, 55% of patients without an exclusionary criteria refused to participate. 20–22, 26, 27 Of the participants randomized to CPAP intervention, for which adherence data were available (N= 165), 48% of those assigned to CPAP were adherent at the last assessment point (online-only Data Supplement Tables II and III).Randomized studies ranged from 1 to 3 months in duration and the total percentage of participants who underwent screening and were available for follow-up was typically 4% to 13%. 20–24, 26 Of the 3473 participants screened in the RCT studies, only 2.3% were CPAP-adherent at the last assessment point (Figure). The Figure illustrates the difficulty associated with isolating a patient population that is eligible, willing to participate in a study, and compliant with the rigors of this type of treatment study.