The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae.
The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae.
复制标题
DOI：
10.15698/mic2017.07.580
复制
发表时间：
2017-07-03
期刊：
影响因子：
--
通讯作者：
Das B
中科院分区：
文献类型：
--
作者：
Das S;Sarkar D;Das B
细胞转录组由特定条件下细胞核中 mRNA 合成速率和细胞质中 mRNA 降解速率决定。过去十年见证了基因表达转录后调控领域令人兴奋的发展，这强调了转录和 mRNA 降解之间强大的功能耦合。功能整合主要由一组专门的启动子和转录因子介导，这些启动子和转录因子通过用称为“协调子”的特定因子“标记”它们来控制其同源转录本的稳定性。消息携带的“标记”随后在细胞质中被解码，这涉及一种或多种 mRNA 衰变因子的刺激，直接通过“协调器”本身或以间接方式。衰减因子的激活反过来导致以选择性方式改变标记信息的稳定性。因此，mRNA合成和衰变之间的整合对于在细胞周期进展、细胞分裂、细胞分化和增殖、应激、免疫和炎症反应过程中塑造适当的基因表达谱发挥着潜在的重要作用，并且可能提高生物进化的速度。
The cellular transcriptome is shaped by both the rates of mRNA synthesis in the nucleus and mRNA degradation in the cytoplasm under a specified condition. The last decade witnessed an exciting development in the field of post-transcriptional regulation of gene expression which underscored a strong functional coupling between the transcription and mRNA degradation. The functional integration is principally mediated by a group of specialized promoters and transcription factors that govern the stability of their cognate transcripts by “marking” them with a specific factor termed “coordinator.” The “mark” carried by the message is later decoded in the cytoplasm which involves the stimulation of one or more mRNA-decay factors, either directly by the “coordinator” itself or in an indirect manner. Activation of the decay factor(s), in turn, leads to the alteration of the stability of the marked message in a selective fashion. Thus, the integration between mRNA synthesis and decay plays a potentially significant role to shape appropriate gene expression profiles during cell cycle progression, cell division, cellular differentiation and proliferation, stress, immune and inflammatory responses, and may enhance the rate of biological evolution.