Corrosion test, cell behavior test, and in vivo study of gradient TiO2 layers produced by compound electrochemical oxidation.
Corrosion test, cell behavior test, and in vivo study of gradient TiO2 layers produced by compound electrochemical oxidation.
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DOI：
10.1002/jbm.a.30745
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发表时间：
2006-09
期刊：
影响因子：
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通讯作者：
Lin Zhu;X. Ye;Guangxin Tang;N. Zhao;Y. Gong;Yuanli Zhao;Ji-zong Zhao;Xiufang Zhang
中科院分区：
文献类型：
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作者：
Lin Zhu;X. Ye;Guangxin Tang;N. Zhao;Y. Gong;Yuanli Zhao;Ji-zong Zhao;Xiufang Zhang
本文描述了通过应用复合氧化的混合技术来改善植入物生物相容性和耐久性的努力。纯钛被用作基底材料。采用微弧氧化法制备了多孔的氧化膜作为外层，采用预阳极氧化法制备了致密的氧化膜作为内层。在这项研究中，物理化学特性，腐蚀试验，细胞附着行为，和在体内的研究被用来比较这种梯度层与未经处理的钛。结果表明，梯度层由金红石和金红石组成的两层氧化膜组成，表面多孔，含有钙和磷。梯度层的耐蚀性显著提高，约为纯钛的3倍，致密层的2倍。细胞-材料相互作用研究表明，L929细胞在梯度层上贴壁良好，增殖速度最快。体内研究表明梯度层具有良好的生物相容性。该梯度层提供了一种具有高耐腐蚀性、生物活性和生物特性的材料，适用于组织工程应用。
This paper describes efforts to improve implant biocompatibility and durability by applying a hybrid technique using composite oxidation. Pure titanium was used as the substrate material. A porous oxide film as the outer layer was produced by micro-arc oxidation and a dense oxide film as the inner layer was produced by pre-anodic oxidation. In this study, physicochemical characteristics, corrosion test, cell attachment behavior, and in vivo studies were used to compare this gradient layer with untreated titanium. The results revealed that the gradient layer was composed of two layers of oxide films which were made up of rutile and anatase and the surface was porous with calcium and phosphor. The corrosion resistance of the gradient layer was improved remarkably, which was about three times the values for titanium and two times the value for the dense layer. The cell-material interaction study indicated that L929 cells seeded and cultured on the gradient layer appeared to attach well and the rate of proliferation was the greatest. The study in vivo showed that the gradient layer had good biocompatibility. This gradient layer provides a material with high corrosion resistance, bioactivity, and biological properties suitable for tissue engineering applications.