Assessment of reproducibility and stability of different breath-hold maneuvres by dynamic MRI:: comparison between healthy adults and patients with pulmonary hypertension
Assessment of reproducibility and stability of different breath-hold maneuvres by dynamic MRI:: comparison between healthy adults and patients with pulmonary hypertension
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DOI：
10.1007/s00330-005-2795-9
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发表时间：
2006-01-01
影响因子：
5.9
通讯作者：
Kauczor, HU
中科院分区：
文献类型：
--
作者：
Plathow, C;Ley, S;Kauczor, HU
使用动态MRI（dMRI）评估健康志愿者和患者不同屏气水平的稳定性和重现性。在10名健康志愿者和10名肺动脉高压（PH）和肺功能正常的患者中，使用dMRI（TrueFISP，3张图像/s）在吸气和呼气屏气（15 s）期间（在健康志愿者中，另外在自我选择的吸气中期屏气时）测量头尾胸内距离（CCD）。为了评价不同屏气水平的稳定性和观察者内重现性，计算CCD、时间-距离曲线、置信区间（CI）、Mann-Witney U检验和回归方程。在健康志愿者中，与呼气屏气相比，吸气屏气期间CCD显著降低。吸气时右侧和左侧半胸的CI分别为2.84 +/-1.28和2.1 +/-0.68。在到期时，CI为2.54 +/-1.18和2.8 +/-1.48。与对照组相比，患者在吸气时的屏气能力显著降低（P <0.05）。患者的CI在吸气时为4.53 +/-4.06和3.46 +/-2.21，呼气时为4.45 +/-4.23和4.76 +/-3.73。观察者内变异性在患者或健康受试者中均无显著差异。在健康志愿者自选的屏气水平下，生殖能力显著降低。DMRI能够区分不同屏气水平的稳定性和再现性。在健康志愿者和患者中，呼气屏气被证明比吸气屏气更稳定。
To assess the stability and reproducibility of different breath-hold levels in healthy volunteers and patients using dynamic MRI (dMRI). In ten healthy volunteers and ten patients with pulmonary hypertension (PH) and normal lung function craniocaudal intrathoracic distances (CCD) were measured during inspiratory and expiratory breath-hold (15 s) (in healthy volunteers additionally at a self-chosen mid-inspiratory breath-hold) using dMRI (trueFISP, three images/s). To evaluate stability and intraobserver reproducibility of the different breath-hold levels, CCDs, time-distance curves, confidence intervals (CIs), Mann-Witney U test and regression equations were calculated. In healthy volunteers there was a substantial decrease of the CCD during the inspiratory breath-hold in contrast to the expiratory breath-hold. The CI at inspiration was 2.84 +/- 1.28 in the right and 2.1 +/- 0.68 in the left hemithorax. At expiration the CI was 2.54 +/- 1.18 and 2.8 +/- 1.48. Patients were significantly less able to hold their breath at inspiration than controls (P < 0.05). In patients CI was 4.53 +/- 4.06 and 3.46 +/- 2.21 at inspiration and 4.45 +/- 4.23 and 4.76 +/- 3.73 at expiration. Intraobserver variability showed no significant differences either in patients or in healthy subjects. Reproducibility was significantly lower at a self-chosen breath-hold level of the healthy volunteers. DMRI is able to differentiate stability and reproducibility of different breath-hold levels. Expiratory breath-hold proved to be more stable than inspiratory breath-hold in healthy volunteers and patients.