ACTIVATION WITHIN DORSAL MEDULLARY NUCLEI FOLLOWING STIMULATION IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS IN RATS
ACTIVATION WITHIN DORSAL MEDULLARY NUCLEI FOLLOWING STIMULATION IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS IN RATS
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DOI：
10.1007/bf00581165
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发表时间：
1987-05-01
影响因子：
4.5
通讯作者：
HARRIS, MC
中科院分区：
文献类型：
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作者：
BANKS, D;HARRIS, MC
在71只乌拉坦/矢状神经麻醉的大鼠上，观察了下丘脑室旁核（PVN）对延髓背侧神经元的影响。536神经元定位和测试的电刺激迷走神经和/或PVN的反应，378个突触或逆向激活迷走神经刺激后，其中72个突触激活PVN内的刺激。在孤束核尾侧，大多数位于孤束核与迷走神经背核的交界处。无一例出现心律失常。显示这种节律的神经元不受PVN的影响。在迷走神经背核的89个神经元中，有10个被室旁核突触激活，2个被室旁核突触抑制。PVN激活的神经元在NTS测试的动脉压力感受器和颈动脉体化学感受器的刺激的反应是不受影响或抑制，但胃膨胀兴奋他们。结果表明，一个强大的PVN的影响，在延髓背侧，这在很大程度上是局限于腹侧和尾侧NTS。几乎没有证据表明对具有心血管功能的神经元有影响，但腹部迷走神经的影响表明与进食有关。
The influence of the hypothalamic paraventricular nucleus (PVN) on neurones in the dorsal medulla has been examined in 71 urethane/sagatal-anaesthetised rats. Of 536 neurones localised and tested for responses to electrical stimulation of both the vagus and/or the PVN, 378 were synaptically or antidromically activated following vagal stimulation 72 of which were synaptically activated by stimulation within PVN. The majority of those were located at the border between NTS and dorsal motor nucleus of the vagus in caudal NTS. None showed cardiac or ventilatory rhythm. Neurones showing such rhythms were not affected from PVN. Of 89 neurones in dorsal motor nucleus of the vagus, ten were synaptically activated and two synaptically depressed from PVN. PVN activated neurones in NTS tested for responses to stimulation of arterial baroreceptors and carotid body chemoreceptors were either unaffected or inhibited, but gastric inflation excited them. The results suggest a powerful PVN influence on the dorsal medulla, which is largely confined to the ventral and caudal NTS. There is little evidence for an effect on neurones with a cardiovascular function, but the abdominal vagal influence suggests a link with feeding.