Scavenging 4-Oxo-2-nonenal
Scavenging 4-Oxo-2-nonenal
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DOI：
10.1021/acs.chemrestox.5b00301
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发表时间：
2015-10-01
影响因子：
4.1
通讯作者：
Amarnath, Kalyani
中科院分区：
文献类型：
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作者：
Amarnath, Venkataraman;Amarnath, Kalyani
4-氧代-2-壬烯醛(ONE)是细胞脂质氧化的产物，与蛋白质的赖氨酸残基发生非特异性反应，在退行性疾病和癌症期间产生的数量增加。结果表明，吡哆胺、水杨胺和相关的2-氨基甲基酚与吡哆胺反应生成吡咯并[2，1-b][1，3]恶嗪，氨基和酚基都参与其中。2-氨基甲基苯酚与1和1的Michael加合物的反应速度比赖氨酸快得多，这表明它们用于治疗清除1。
4-Oxo-2-nonenal (ONE), a product of cellular lipid oxidation, reacts nonspecifically with the lysine residues of proteins and is generated in increased amounts during degenerative diseases and cancer. We show that pyridoxamine, salicylamine, and related 2-aminomethylphenols react with ONE, to form pyrrolo[2,1-b][1,3]oxazines with the participation of both the amino and the phenolic groups. 2-Aminomethylphenols react with ONE as well as with the Michael adducts of ONE much more rapidly than lysine, suggesting their use for therapeutically scavenging ONE.