Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460
Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460
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DOI：
10.1007/s13277-014-1677-7
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发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Wang, Qiu-Shi
中科院分区：
文献类型：
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作者：
Cui, Wen-Yao;Liu, Yan;Wang, Qiu-Shi
异丙酚是肿瘤切除手术中最常用的静脉麻醉药之一。它可以在体外和体内影响癌细胞的增殖、运动和侵袭。然而，丙泊酚在肺癌细胞中的作用尚不清楚。本研究采用集落形成实验和流式细胞术观察异丙酚对肺癌细胞H460增殖和凋亡的影响。异丙酚也降低了已建立的异种移植肿瘤的大小和重量。Western blot检测丙泊酚诱导的内质网应激。
Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. It can influence proliferation, motility, and invasiveness of cancer cells in vitro and in vivo. However, the role of the propofol in the lung cancer cells remains unclear. In this study, we demonstrated the effects of propofol on the proliferation and the apoptosis of lung cancer cell H460 by using colony formation assay and flow cytometry. Propofol also decreased tumor size and weight in established xenografted tumors. Furthermore, propofol-induced endoplasmic reticulum (ER) stress was determined by Western blot.