Parkinson's disease and weight loss: a study with anthropometric and nutritional assessment.
Parkinson's disease and weight loss: a study with anthropometric and nutritional assessment.
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DOI：
10.1007/bf01818955
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发表时间：
1992-06-01
期刊：
影响因子：
--
通讯作者：
Montastruc, J L
中科院分区：
文献类型：
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作者：
Durrieu, G;LLau, M E;Montastruc, J L
为了调查帕金森病患者的假定体重减轻，进行了人体测量和生化研究。我们比较了患有特发性帕金森病的男性和女性与正常对照组的体重和脂肪指数[体重指数（BMI），躯干皮褶厚度]和瘦体重[上臂肌面积（MMA），小腿围]。我们发现，与对照组相比，患有帕金森病的女性体重显著减轻（-8.5%），小腿围减小。帕金森氏症患者的总体重也有所下降（-4.3%），但差异未达到显著水平。帕金森病患者营养状况的蛋白生化标志物（白蛋白、前白蛋白、视黄醇结合蛋白、转铁蛋白）均正常。目前的研究表明，体重减轻的发生在一个大的人口与帕金森氏病患者。假定的机制参与的重量损失进行了讨论。
In order to investigate a putative weight loss in patients with Parkinson's disease, an anthropometric and biochemical study was undertaken. We compared body weight and indexes of fat [body mass index (BMI), tricipital skinfold] and lean [midarm muscle area (MMA), calf circumference] mass in men and women suffering from idiopathic Parkinson's disease with normal controls. We found that women suffering from Parkinson's disease exhibited a significant weight loss (-8.5%) and decreased calf circumference when compared with controls. A decrease (-4.3%) in total body weight was also found in men with Parkinson's disease but the difference did not reach the level of significance. Protein biochemical markers of nutritional status (albumin, prealbumin, retinol binding protein, transferrin) were normal in Parkinson's disease patients. The present study demonstrates the occurrence of weight loss in a large population of patients with Parkinson's disease. The putative mechanisms involved in the weight loss are discussed.