Successful treatment and prevention of murine Pneumocystis carinii pneumonitis with 4,4'-sulfonylbisformanilide.
Successful treatment and prevention of murine Pneumocystis carinii pneumonitis with 4,4'-sulfonylbisformanilide.
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用 4,4-磺酰基双甲苯胺成功治疗和预防小鼠卡氏肺囊虫肺炎。
DOI：
10.1128/aac.29.3.509
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发表时间：
1986
影响因子：
4.9
通讯作者：
Jacobus,DP
中科院分区：
文献类型：
--
作者：
Hughes,WT;Smith,BL;Jacobus,DP
每天给予0.5、5.0、25.0和125.0 mg/kg（体重）剂量的4，4 '-磺酰二甲苯胺（DFD），免疫抑制大鼠的卡氏肺孢子虫肺炎预防率分别为0、50、100和100%。DFD以25.0 mg/kg/天的剂量证明了治疗效果，当该剂量与甲氧苄啶组合时，该组合与甲氧苄啶-磺胺甲恶唑一样有效，已证明其在治疗鼠和人卡氏肺孢子虫肺炎中有效。
Pneumocystis carinii pneumonitis was prevented in 0, 50, 100, and 100% of immunosuppressed rats given doses of 0.5, 5.0, 25.0, and 125.0 mg/kg (body weight) per day, respectively, of 4,4'-sulfonylbisformanilide (DFD). Therapeutic efficacy was demonstrated with DFD at 25.0 mg/kg per day, and when this dose was combined with trimethoprim, the combination was as effective as trimethoprim-sulfamethoxazole, which has been proven to be effective in the treatment of murine and human P. carinii pneumonitis.