Temporal relationship between cancers of the lung and upper aerodigestive tract
Temporal relationship between cancers of the lung and upper aerodigestive tract
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DOI：
10.1093/jjco/27.2.63
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发表时间：
1997-04-01
影响因子：
2.4
通讯作者：
Perng, RP
中科院分区：
文献类型：
--
作者：
Hsieh, WC;Chen, YM;Perng, RP
我们回顾了台北退伍军人总医院1985年1月至1994年12月期间的图表记录，以研究肺癌与上气消化道之间的时间关系。共发现56例（男性54例，女性2例）组织细胞学证实的双原发癌，首先出现肺癌或上呼吸道肿瘤。鳞状细胞癌是肺癌最常见的组织学类型（鳞状细胞癌57%，腺癌27%，低分化癌9%，小细胞肺癌7%）。肺癌合并上消化道肿瘤的发生率为0.9%（56/6412）。非小细胞肺癌与小细胞肺癌上消化道肿瘤的发生率比较，差异无统计学意义（P < 0.05）。而鳞肺癌合并上气消化道癌的发生率高于非鳞肺癌（P < 0.05）。至于肺癌的发生部位，右肺比左肺更常见（P < 0.001）。肺癌患者上消化道肿瘤发生部位为：喉24例，鼻咽部11例，食道10例，下咽4例，咽扁桃体2例，口腔5例。大多数上气消化道肿瘤在肺癌前确诊（36/56,64%），超过半数上气消化道肿瘤确诊后3年内确诊肺癌（58.3%）。上气消化道癌发生前的肺癌在诊断时多为早期（ⅰ期4、ⅲ期1、ⅲ期1），而与上气消化道癌同时或在诊断后出现的肺癌多为晚期。肺癌合并上气消化道癌患者与未合并上气消化道癌患者的生存率无统计学差异（P < 0.05）。
We retrospectively reviewed the chart records at the Veterans General Hospital-Taipei for the period between January 1985 and December 1994 to examine the temporal relationship between cancers of the lung and upper aerodigestive tract. A total of 56 patients (54 males, 2 females) with histocytologically proven double primary cancers, with either lung cancer or upper aerodigestive tract cancers appearing first, were found. Squamous cell carcinoma was the most frequent histologic type of lung cancer (squamous 57%, adenocarcinoma 27%, poorly differentiated carcinoma 9%, small cell lung cancer 7%). The incidence of lung cancer patients with upper aerodigestive tract cancer was 0.9% (56/6412). There was no significant difference in the occurrence of upper aerodigestive tract cancer between non-small cell and small cell lung cancer (P > 0.05). However, the incidence of squamous cell lung cancer with upper aerodigestive tract cancer was higher than that of non-squamous cell lung cancer (P < 0.05). With regard to the location of lung cancer, the right lung was more commonly affected than the left (P < 0.001). The locations of upper aerodigestive tract cancers in these lung cancer patients were as follows: larynx 24, nasopharynx 11, esophagus 10, hypopharynx 4, pharyngeal tonsils 2, oral cavity 5. Most upper aerodigestive tract cancers were diagnosed before lung cancer (36/56, 64%), and lung cancer was diagnosed within 3 years in more than half of cases after the diagnosis of upper aerodigestive tract cancer (58.3%). Most lung cancers that preceded upper aerodigestive tract cancer were at an early stage at diagnosis (stage I 4, stage IIIa 1), whereas the others, appearing either synchronously or after the diagnosis of upper aerodigestive tract cancer, were mostly at the late stage. There was no difference in survival between lung cancer patients with upper aerodigestive tract cancer and those without (P > 0.05).