QUANTIFIED ELECTROGRAPHIC SCALES ON 10 PRE-TERM HEALTHY NEWBORNS FOLLOWED UP TO 40-43 WEEKS OF CONCEPTIONAL AGE BY SERIAL POLYGRAPHIC RECORDINGS
QUANTIFIED ELECTROGRAPHIC SCALES ON 10 PRE-TERM HEALTHY NEWBORNS FOLLOWED UP TO 40-43 WEEKS OF CONCEPTIONAL AGE BY SERIAL POLYGRAPHIC RECORDINGS
复制标题
DOI：
10.1016/0013-4694(79)90147-0
复制
发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
LOMBROSO, CT
中科院分区：
文献类型：
--
作者：
LOMBROSO, CT
在一项前瞻性研究中，足月人类新生儿癫痫发作表现出的EEG模式在预测神经学结局方面似乎可靠，几乎占75%。这些模式对于> 25%的癫痫发作婴儿是不可靠的，对于有其他并发症的足月和早产儿更是如此。这样的新生儿往往表现出成熟延迟的各种生理和/或行为参数的观察，提出了一个问题，是否比特定的EEG模式以外的指数可能证明可靠的预测预后。作为一个先决条件，以测试这样一个假设，在前瞻性调查的长期和早产儿的风险因素以外的癫痫发作，它似乎有必要获得这些参数的量化正常。一项纵向研究的目的是同时获得3个参数的对照组出生后30-32周的胎龄的新生儿，随后连续多导记录在每周的时间间隔，直到43周的概念年龄。所选参数被有意限制为3个，这些参数可以在常规记录中轻松获得和测量，而无需更复杂的仪器和分析。这些是：迹线交替的突发之间的半球间同步的百分比;纺锤体-δ的数目。复合物（刷）在5分钟的REM [快速眼动]和N[非]REM睡眠;和各种参数之间的一致性，在相同的5分钟时期。这些指标的范围是在一组正常早产儿中建立的。建立这样的规范性数据将允许更大的研究间的可靠性，并形成其他的风险婴儿的前瞻性研究的基础，以调查是否那些落后于这些指标在新生儿期连续随访时，从那些谁恢复和达到预期的正常受孕年龄的标准有明显不同。
Full-term human newborns with seizures exhibit EEG patterns that appear reliable in predicting neurological outcome in almost 75% of the cases in a prospective investigation. These patterns are unreliable for > 25% of infants with seizures and even more so for term and pre-term babies with other complications. Observations that such newborns often show maturational delay in various physiological and/or behavioral parameters, raises the issue of whether indices other than specific EEG patterns might prove reliable in predicting prognosis. As a prerequisite for testing such an hypothesis in prospective investigations of term and pre-term babies with risk factors other than seizures, it appears necessary to obtain quantification of these parameters in normals. A longitudinal study was designed to obtain simultaneously 3 parameters in a control group of newborns born after 30-32 wk of gestational age, followed with serial polygraphic recordings at weekly intervals until a conceptional age of 43 wk. The selected parameters were purposefully restricted to 3 that can be obtained and measured easily in routine recordings without need for more complex instrumentation and analysis. These were: the percentage of interhemispheric synchrony between bursts of trace alternant; the number of spindle-.delta. complexes (brushes) during 5 min of REM [rapid eye movement] and N[non]REM sleep; and the concordance between various parameters during the same 5 min epochs. The range of these indices was established in a group of normal prematures followed prospectively. Establishing such normative data will allow greater inter-study reliability, and form the basis for other prospective studies of infants at risk to investigate whether those that lag behind the norm in these indices when followed serially during the newborn period differ prognostically from those who recover and reach expected norms for conceptional age.