Sensory gating in chronic posttraumatic stress disorder: Reduced auditory P50 suppression in combat veterans
Sensory gating in chronic posttraumatic stress disorder: Reduced auditory P50 suppression in combat veterans
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DOI：
10.1016/s0006-3223(99)00047-5
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发表时间：
1999-12-15
影响因子：
10.6
通讯作者：
Fein, G
中科院分区：
文献类型：
--
作者：
Neylan, TC;Fletcher, DJ;Fein, G
背景：创伤后应激障碍（PTSD）可能与认知功能的一般损害有关，这种损害超出了创伤特异性刺激的处理范围。正常受试者对重复刺激的听觉P50反应受到抑制，反映了中枢神经系统屏蔽重复刺激的能力，这种现象被称为感觉门控。本研究考察了PTSD受试者和正常人对非惊吓性听觉刺激的P50感觉门控。方法：采用条件反射/测试范式对15例PTSD男性患者和12例男性对照进行P50生成和门控研究。P50测试/调理（T/C）比率采用奇异值分解法估计。结果：PTSD受试者对条件刺激的P50反应幅度与正常对照无显著差异。与对照组（均值= .213,SD = .126，双尾T， p = .024）相比，PTSD患者的P50 T/C比值（均值= .408,SD = .275）明显增加。结论：本研究提供了PTSD与非惊吓性创伤中性听觉刺激门控受损相关的证据。
Background: Posttraumatic stress disorder (PTSD) may be associated with a general impairment of cognitive function that extends beyond the processing of trauma-specific stimuli Suppression of the auditory P50 response to repeated stimuli occurs in normal subjects and reflects the central nervous system's ability to screen out repetitive stimuli, a phenomenon referred to as sensory gating. This study examines P50 sensory gating to nonstartle auditory stimuli in PTSD subjects and normal controls.Methods: P50 generation and gating were studied using a conditioning/testing paradigm in 15 male subjects with PTSD and 12 male controls. P50 test/conditioning (T/C) ratios were estimated using the Singular Value Decomposition method.Results: The amplitude of the P50 response to the conditioning stimulus did nor differ in subjects with PTSD compared to normal controls. The P50 T/C ratio is increased in PTSD subjects (mean = .408, SD = .275) as compared to the controls (mean = .213, SD = .126, two tailed t, p = .024),Conclusions: This study provides evidence that PTSD is associated with impaired gating to nonstartle trauma-neutral auditory stimuli Biol Psychiatry 1999;46:1656-1664.