Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors
Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors
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DOI：
10.1109/2944.796320
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发表时间：
1999-07-01
影响因子：
4.9
通讯作者：
Oraevsky, AA
中科院分区：
文献类型：
--
作者：
Esenaliev, RO;Karabutov, AA;Oraevsky, AA
目前的成像方式无法检测到乳房中的小肿瘤。光声层析成像是一种新的早期癌症检测技术，具有很好的诊断能力。研究了位于块状体模组织内的小模型肿瘤的激光光声检测的灵敏度和最大深度的实验极限。在这些研究中使用了两种在近红外光谱范围内具有与乳腺组织相似的光学特性的体模：100 mm厚的浑浊明胶片和80 mm厚的鸡胸肉片，使用相对于背景吸收和肝组织具有增强的吸收系数的明胶球来模拟小肿瘤。实验证明了激光光声成像检测和定位明胶模体内直径为2 mm、深度达60 mm的模体肿瘤和80 mm鸡胸组织内3 x 2 x 0.6 mm肝组织块的能力。并利用实验数据计算了小肿瘤的吸收系数。我们的研究结果表明，光声成像可能会占据一个显着的利基在乳腺癌和其他器官的早期检测。
Current imaging modalities fail to detect small tumors in the breast. Opto-acoustic tomography is a novel technique for early cancer detection with promising diagnostic capability. The experimental limit of sensitivity and maximal depth of the laser opto-acoustic detection for small model tumors located within bulk phantom tissue were studied, Two phantoms with optical properties similar to that of breast tissue in the near infrared spectral range were used in these studies: turbid gelatin slabs with the thickness of 100 mm and chicken breast muscle slabs with the thickness of up to 80 mm, Gelatin spheres with enhanced absorption coefficient relative to the background absorption and liver tissue were used to simulate small tumors. The experiments demonstrated the capability of laser optoacoustic imaging to detect and localize phantom tumors with the diameter of 2 mm at a depth of up to 60 mm within the gelatin phantoms and 3 x 2 x 0.6-mm piece of liver tissue within 80-mm chicken breast tissue, Theoretical studies on sensitivity of opto-acoustic detection at various diameters, depths of location, and absorption coefficients of small tumors mere performed using the experimental data. Our results suggest that the opto-acoustic imaging may occupy a significant niche in early detection of cancer in the breast and other organs.