An Outbreak of Canine Distemper Virus in Tigers (Panthera tigris): Possible Transmission from Wild Animals to Zoo Animals
An Outbreak of Canine Distemper Virus in Tigers (Panthera tigris): Possible Transmission from Wild Animals to Zoo Animals
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DOI：
10.1292/jvms.11-0509
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发表时间：
2012-06-01
影响因子：
1.2
通讯作者：
Maeda, Ken
中科院分区：
文献类型：
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作者：
Nagao, Yumiko;Nishio, Yohei;Maeda, Ken
犬瘟热病毒(CDV)是一种麻疹病毒，可引起已知的犬类中最具传染性和致命性的病毒性疾病之一，其宿主范围不断扩大，包括野生动物。自2009年12月以来，在日本一家狩猎式动物园及其周围发现了几只死亡或濒临死亡的野生浣熊(Nyctereuts Pryonoides)，并从其中四只动物身上分离出了CDV。在接下来的几个月里(2010年1月至2月)，动物园里的12只老虎(Panthera Tigris)出现了呼吸道和胃肠道疾病，在被检查的老虎的粪便样本中检测到CDV RNA。2010年3月，其中一只老虎患上神经疾病并死亡；从该动物的肺中分离出CDV。全血凝素(H)基因和融合(F)基因信号肽的序列分析表明，这些分离株之间有很高的同源性(99.8%~100%)，表明CDV可能是从浣熊传播到老虎的。此外，这些分离株属于基因Asia-1，同源性较低(
Canine distemper virus (CDV), a morbillivirus that causes one of the most contagious and lethal viral diseases known in canids, has an expanding host range, including wild animals. Since December 2009, several dead or dying wild raccoon dogs (Nyctereutes procyonoides) were found in and around one safari-style zoo in Japan, and CDV was isolated from four of these animals. In the subsequent months (January to February 2010), 12 tigers (Panthera tigris) in the zoo developed respiratory and gastrointestinal diseases, and CDV RNA was detected in fecal samples of the examined tigers. In March 2010, one of the tigers developed a neurological disorder and died; CDV was isolated from the lung of this animal. Sequence analysis of the complete hemagglutinin (H) gene and the signal peptide region of the fusion (F) gene showed high homology among these isolates (99.8-100%), indicating that CDV might have been transmitted from raccoon dog to tiger. In addition, these isolates belonged to genotype Asia-1 and had lower homology (