Modelling charge transport in DNA using transfer matrices with diagonal terms
Modelling charge transport in DNA using transfer matrices with diagonal terms
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DOI：
10.1142/s0217979209063328
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发表时间：
2009-08
影响因子：
1.7
通讯作者：
S. Wells;C. Shih;R. Römer
中科院分区：
文献类型：
--
作者：
S. Wells;C. Shih;R. Römer
越来越多的证据表明，DNA可以通过空穴从一个碱基跳跃到另一个碱基来支持相当程度的电荷沿着链的沿着传输，并且这种电荷传输可能与DNA调节、损伤检测和修复有关。一个令人惊讶的有用量的洞察力可以从简单的紧密结合的电荷传输模型的建设，可以使用转移矩阵法进行调查。由此获得的数据表明DNA电荷传输特性与癌性突变的位置之间的相关性。我们审查模型的DNA电荷传输及其扩展，包括物理上更现实的对角跳跃条款。
There is increasing evidence that DNA can support a considerable degree of charge transport along the strand by hopping of holes from one base to another, and that this charge transport may be relevant to DNA regulation, damage detection and repair. A surprisingly useful amount of insight can be gained from the construction of simple tight-binding models of charge transport, which can be investigated using the transfer-matrix method. The data thus obtained indicate a correlation between DNA charge-transport properties and the locations of cancerous mutation. We review models for DNA charge transport and their extension to include more physically realistic diagonal-hopping terms.