Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes
Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes
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DOI：
10.1152/ajpheart.01339.2006
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发表时间：
2007-07-01
影响因子：
4.8
通讯作者：
Katz, Stuart D.
中科院分区：
文献类型：
--
作者：
Dewland, Thomas A.;Androne, Ana Silvia;Katz, Stuart D.
心率变异性和运动后心率恢复在人体研究中用于评估心脏副交感神经张力，但在某些情况下，这些指标似乎产生不一致的信息。我们利用吡啶斯的明，乙酰胆碱酯酶抑制剂，选择性增强副交感神经传出信号，以进一步表征副交感神经调节休息和运动后心率。在随机、双盲、交叉试验中，我们测量了10名久坐不动的成年人和10名有氧训练的运动员单剂量口服吡啶斯的明（30 mg）和匹配的安慰剂后静息心率变异性和运动后心率恢复的时域和频域指标。在久坐的成年人中，吡啶斯的明降低静息心率[从66.7（SD 12.6）降至58.1次/分（SD 7.6），P = 0.005 vs.安慰剂]，增加运动后1分钟心率恢复[从40.7（SD 10.9）降至45.1次/分（SD 8.8），P = 0.02 vs.安慰剂]。在训练过的运动员中，与安慰剂相比，吡啶斯的明没有改变静息心率或运动后心率恢复。静息心率变异性的时域和频域指标在两个队列中吡啶斯的明与安慰剂治疗后均无差异，且与运动后心率恢复无显著相关性。吡啶斯的明对久坐受试者心脏副交感神经功能的静息和运动后测量的不同影响证实了这些测量表征了心脏副交感神经调节的不同方面。吡啶斯的明对受训运动员心脏副交感神经张力的影响较小，表明与运动训练相关的副交感神经张力增强至少部分归因于传出副交感神经通路的适应。
Heart rate variability and postexercise heart rate recovery are used to assess cardiac parasympathetic tone in human studies, but in some cases these indexes appear to yield discordant information. We utilized pyridostigmine, an acetylcholinesterase inhibitor that selectively augments the parasympathetic efferent signal, to further characterize parasympathetic regulation of rest and postexercise heart rate. We measured time- and frequency-domain indexes of resting heart rate variability and postexercise heart rate recovery in 10 sedentary adults and 10 aerobically trained athletes after a single oral dose of pyridostigmine ( 30 mg) and matching placebo in randomized, doubleblind, crossover trial. In sedentary adults, pyridostigmine decreased resting heart rate [from 66.7 (SD 12.6) to 58.1 beats/min (SD 7.6), P = 0.005 vs. placebo] and increased postexercise heart rate recovery at 1 min [from 40.7 (SD 10.9) to 45.1 beats/min (SD 8.8), P = 0.02 vs. placebo]. In trained athletes, pyridostigmine did not change resting heart rate or postexercise heart rate recovery when compared with placebo. Time- and frequency-domain indexes of resting heart rate variability did not differ after pyridostigmine versus placebo in either cohort and were not significantly associated with postexercise heart rate recovery in either cohort. The divergent effects of pyridostigmine on resting and postexercise measures of cardiac parasympathetic function in sedentary subjects confirm that these measures characterize distinct aspects of cardiac parasympathetic regulation. The lesser effect of pyridostigmine on either measure of cardiac parasympathetic tone in the trained athletes indicates that the enhanced parasympathetic tone associated with exercise training is at least partially attributable to adaptations in the efferent parasympathetic pathway.