Herpesvirus antibody levels in the etiologic diagnosis of the acute retinal necrosis syndrome.

Herpesvirus antibody levels in the etiologic diagnosis of the acute retinal necrosis syndrome.
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疱疹病毒抗体水平在急性视网膜坏死综合征病因诊断中的作用。

DOI:
10.1016/s0002-9394(14)71575-2
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发表时间:
1992
影响因子:
4.2
通讯作者:
Kreiger,AE
Kreiger,AE
中科院分区:
医学1区
文献类型:
--
作者:
Pepose,JS;Flowers,B;Stewart,JA;Grose,C;Levy,DS;Culbertson,WW;Kreiger,AE

文献摘要

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被引文献

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定量抗体水平的急性和慢性血清中的三种疱疹病毒的急性视网膜坏死综合征的临床症状的6例患者是一致的,只有在两个案件与皮肤带状疱疹的具体病因诊断。除了来自文献的27例急性视网膜坏死病例的数据外,这6例患者的疱疹组病毒急性和恢复期抗体滴度的可用数据显示,33例患者中只有13例(39%)在连续采样时疱疹组病毒抗体水平诊断性升高或降低。尽管玻璃体疱疹病毒培养呈阳性,但三名患者的病毒抗体水平出现非诊断性变化。与此相反,回顾了25例配对的抗病毒血清和眼内液抗体水平的文献,提出了一个更有前途的方法,急性视网膜坏死综合征的病因诊断。通过计算眼内液和血清中抗病毒抗体的比值,14例亚急性期和恢复期样本中有12例(86%)可作出病原学诊断。当在病程早期获得液体时,该方法的灵敏度降低至72%(18例中的13例)。
Quantitative antibody levels to three herpesviruses in acute and chronic sera from six patients with clinical signs of the acute retinal necrosis syndrome were consistent with a specific etiologic diagnosis only in the two cases associated with cutaneous herpes zoster. Available data on acute and convalescent antibody titers to herpes group viruses from these six patients in addition to data from 27 acute retinal necrosis cases from the literature disclosed that only 13 of the 33 patients (39%) had a diagnostic increase or decrease in herpes group viral antibody levels on serial sampling. Three patients had nondiagnostic changes in viral antibody levels despite positive vitreous cultures for herpesviruses. In contrast, a review of 25 cases from the literature with paired antiviral serum and intraocular fluid antibody levels suggested a more promising approach to the etiologic diagnosis of the acute retinal necrosis syndrome. By calculating the ratio of antiviral antibodies in intraocular fluid and serum, an etiologic diagnosis could be made in 12 of 14 (86%) of subacute and convalescent samples. The sensitivity of this method decreased to 72% (13 of 18) when fluids were obtained earlier in the course of the disease.
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