Retinal and cerebral microvascular signs and diabetes - The age, Gene/Environment Susceptibility-Reykjavik Study
Retinal and cerebral microvascular signs and diabetes - The age, Gene/Environment Susceptibility-Reykjavik Study
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DOI：
10.2337/db07-1455
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发表时间：
2008-06-01
期刊：
影响因子：
7.7
通讯作者：
Lanner, Lenore J.
中科院分区：
文献类型：
--
作者：
Qiu, Chengxuan;Cotch, Mary Frances;Lanner, Lenore J.
糖尿病增加微血管疾病的风险。视网膜和大脑都有复杂的微血管系统，它们在发育上是相似的。我们试图研究是否在视网膜和大脑中的微血管病变是相关的，这种关联是否不同的人与非diabetes.RESEARCH设计和方法，分析包括4,218名参与者的冰岛人口为基础的年龄，基因/环境易感性雷克雅未克研究谁出生于1907年至1935年，谁是以前的雷克雅未克研究的一部分。在双眼的数字视网膜图像上评价视网膜局灶性小动脉狭窄、动静脉（AV）切口和微动脉瘤/微血管瘤。脑微出血（CMB）的磁共振图像进行了评价。数据用逻辑和多项逻辑回归模型分析，控制人口统计学、主要心血管危险因素、脑梗死和白色病变。在485例（11.5%）人中发现了脑微出血的证据，包括192例多次（>= 2）微出血。有视网膜微血管病变体征的受试者患多个CMB的可能性显著增加，糖尿病患者合并视网膜AV切口（比值比[OR] 2.47 [95% CI 1.42-4.31]）或视网膜微动脉瘤/视网膜血管瘤（2.28 [1.24-4.18]）明显更可能有多个CMB. CONCLUSION视网膜微血管异常和脑微出血可能发生在老年人一起。患有糖尿病和视网膜微血管病变（AV切口和微动脉瘤/血管瘤）的人更有可能在大脑中有多个微出血。糖尿病的微血管疾病会扩展到大脑。
OBJECTIVE-Diabetes increases the risk for microvascular disease. The retina and the brain both have intricate microvascular systems that are developmentally similar. We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes.RESEARCH DESIGN AND METHODS-The analysis included 4,218 participants of the Icelandic population-based Age, Gene/Environment Susceptibility-Reykjavik Study who were born in 1907-1935 and who were previously followed as a part of the Reykjavik Study. Retinal focal arteriolar narrowing, arteriovenous (AV) nicking, and microaneurysms/hemorrhages were evaluated on digital retinal images of both eyes. Cerebral micro-bleeds (CMBs) were evaluated from magnetic resonance images. Data were analyzed with logistic and multinomial logistic regression models controlling for demographics, major cardiovascular risk factors, cerebral infarcts, and white matter lesions.RESULTS-Evidence of brain microbleeds was found in 485 (11.5%) people, including 192 with multiple ( >= 2) microbleeds. Subjects with signs of retinal microvascular lesions were at a significantly increased likelihood for having multiple CMBs, People with diabetes in combination with the presence of either retinal AV nicking (odds ratio [OR] 2.47 [95% CI 1.42-4.31]) or retinal microaneurysms/hemorrhages (2.28 [1.24-4.18]) were significantly more likely to have multiple CMBs.CONCLUSIONS-Retinal microvascular abnormalities and brain microbleeds may occur together in older adults. People with both diabetes and signs of retinal microvascular lesions (AV nicking and microaneurysms/hemorrhages) are more likely to have multiple microbleeds in the brain. Microvascular disease in diabetes extends to the brain.