Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal and intra-muscular administration of microsphere co-encapsulated Yersinia pestis sub-unit vaccines
Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal and intra-muscular administration of microsphere co-encapsulated Yersinia pestis sub-unit vaccines
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DOI：
10.1016/s0264-410x(98)00089-9
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发表时间：
1998-12-01
期刊：
影响因子：
5.5
通讯作者：
Alpar, HO
中科院分区：
文献类型：
--
作者：
Eyles, JE;Spiers, ID;Alpar, HO
用混合鼠疫菌亚单位（3 μ g V, 0.47 μ g F1）或同等剂量的聚l -丙交酯微球共包封抗原进行气管、鼻腔和肌肉内免疫。根据免疫途径和亚单位的包封状态，对F1和V的全身和粘膜反应不同。无论免疫部位如何，颗粒亚单位刺激的原发性全身反应在统计学上更优越，与肌肉内注射免费疫苗相比，气管内和鼻腔微球免疫可诱导更高的血清抗- v IgG滴度(p
Intra-tracheal, intra-nasal and intra-muscular immunisation with admixed Y. pestis sub-units (3 mu g V, 0.47 mu g F1) or equivalent doses of poly-L-lactide microsphere co-encapsulated antigens was done. Systemic and mucosal responses to F1 and V differed according to immunisation route, and encapsulated status of the sub-units. Irrespective of immunisation site, particulated sub-units stimulated statistically superior primary systemic reactions, with intra-tracheal and nasal microsphere immunisations eliciting superior serum anti-V IgG titres in comparison to intra-muscular injection of free vaccines (p