Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia
Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia
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DOI：
10.1016/j.neulet.2010.01.080
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发表时间：
2010-03-26
影响因子：
2.5
通讯作者：
Ueda, Hiroshi
中科院分区：
文献类型：
--
作者：
Nishiyori, Michiko;Nagai, Jun;Ueda, Hiroshi
暴露于间歇性冷应激 (ICS) 而非持续冷应激 (CCS) 的小鼠表现出持续的热痛觉过敏长达 12 天。全身或脑室内（i.c.v.）注射吗啡对 ICS 小鼠没有产生明显的镇痛作用，但在对照小鼠中引起剂量依赖性镇痛。然而，鞘内或跖内注射吗啡却取得了显着的镇痛效果。 i.c.v.注射吗啡显着增加了对照小鼠脊髓背半部的周转率（5-HIAA/5-HT），但在 ICS 小鼠中则不然。总的来说，这些结果表明，下降的血清素激活的丧失似乎是吗啡诱导镇痛作用缺失的关键机制。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Mice exposed to intermittent cold stress (ICS), but not constant cold stress (CCS) showed sustained thermal hyperalgesia for up to 12 days. Systemic or intracerebroventricular (i.c.v.) injection of morphine caused no significant analgesia in ICS mice, but induced dose-dependent analgesia in control mice. However, significant analgesic effects were achieved by intrathecal or intraplantar injection of morphine. The i.c.v. injection of morphine significantly increased the turnover ratio (5-HIAA/5-HT) in the dorsal half of the spinal cord of control mice, but not in ICS mice. Collectively, these results indicate that the loss of descending serotonergic activation seems to be a key mechanism underlying the absence of morphine-induced analgesia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.