Activation of ERβ modulates fear generalization through an effect on memory retrieval
Activation of ERβ modulates fear generalization through an effect on memory retrieval
复制标题
DOI：
10.1016/j.yhbeh.2014.06.017
复制
发表时间：
2014-07-01
影响因子：
3.5
通讯作者：
Jasnow, Aaron M.
中科院分区：
文献类型：
--
作者：
Lynch, Joseph F., III;Dejanovic, Dina;Jasnow, Aaron M.
女性患焦虑症的可能性比男性高60%。这种差异的一个假设可能是，女性表现出更高的恐惧泛化速度。女性比男性更快地将恐惧概括为中性环境，这一过程在一定程度上是由雌激素驱动的。在本研究中，去卵巢的成年雌性Long-Evans大鼠在被动回避过程中被急性注射苯甲酸雌二醇(15微克/0.1毫升芝麻油)或芝麻油，以确定雌激素是通过影响恐惧记忆的获得/巩固还是通过恐惧记忆恢复来增加恐惧概化。训练前1h注射的动物一般在训练后24小时进入中性环境，而不是训练后7天。当注射发生在测试前24小时时，也可以看到泛化，但当在即刻(1小时)或中间(6小时)时间点进行测试时，则不是这样。在实验3中，动物被注射雌激素受体激动剂，PPT或DPN，以确定哪个ER亚型(S)增加了恐惧的概括性。当测试发生在注射后24小时时，只有ERβ激动剂DPN增加了恐惧泛化。我们的结果表明，雌二醇通过激活ERβ而影响恐惧记忆提取机制，从而增加恐惧泛化。由爱思唯尔公司出版。
Women are 60% more likely to suffer from an anxiety disorder than men. One hypothesis for this difference may be that females exhibit increased rates of fear generalization. Females generalize fear to a neutral context faster than males, a process driven, in part, by estrogens. In the current study, ovariectomized adult female Long-Evans rats were given acute injections of estradiol benzoate (15 mu g/0.1 mL sesame oil) or sesame oil during a passive avoidance procedure to determine if estrogens increase fear generalization through an effect on fear memory acquisition/consolidation or through fear memory retrieval. Animals injected 1 h prior to training generalized to the neutral context 24 h later but not 7 days after training. Generalization was also seen when injections occurred 24 h before testing, but not when tested at immediate (1 h) or intermediate (6 h) time points. In Experiment 3, animals were injected with estrogen receptor (ER) agonists, PPT or DPN, to determine which ER subtype(s) increased fear generalization. Only the ER beta agonist, DPN, increased fear generalization when testing occurred 24h after injection. Our results indicate that estradiol increases fear generalization through an effect on fear memory retrieval mechanisms by activation of ER beta. Published by Elsevier Inc.