Independent representations of reward-predicting cues and reward history in frontal cortical neurons
Independent representations of reward-predicting cues and reward history in frontal cortical neurons
复制标题
额叶皮层神经元奖励预测线索和奖励历史的独立表示
DOI：
10.1101/2020.01.23.916460
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Matsuzaki Masanori
中科院分区：
文献类型：
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作者：
Kondo Masashi;Matsuzaki Masanori
将感官输入转换为适当的目标导向行动需要基于结果历史来估计感官线索值。为了阐明皮质神经元如何代表结果预测线索和实际结果，我们在经典条件反射任务的执行过程中对小鼠新皮质进行了宽场和双光子钙成像，其中两种线索具有不同的水奖励概率。虽然舔行为占主导地位的区域平均活动在整个背侧新皮层，背内侧额叶皮层（dmFrC）影响其他背侧额叶皮层的活动，其抑制熄灭的差异预期舔之间的线索。在单个额叶皮层神经元中，奖励预测线索与当前或过去的奖励不同时表示，但舔行为经常与奖励预测线索和当前或过去的奖励复用。深层神经元在dmFrC最强烈的代表奖励预测线索和最近的奖励历史。我们的研究结果表明，这些神经元点燃皮层过程所需的选择适当的行动。
The transformation of sensory inputs to appropriate goal-directed actions requires estimation of sensory-cue values based on outcome history. To clarify how cortical neurons represent an outcome-predicting cue and actual outcome, we conducted wide-field and two-photon calcium imaging of the mouse neocortex during performance of a classical conditioning task with two cues with different water-reward probabilities. Although licking behavior dominated the area-averaged activity over the whole dorsal neocortex, dorsomedial frontal cortex (dmFrC) affected other dorsal frontal cortical activities, and its inhibition extinguished differences in anticipatory licking between the cues. In individual frontal cortical neurons, the reward-predicting cue was not simultaneously represented with the current or past reward, but licking behavior was frequently multiplexed with the reward-predicting cue and current or past reward. Deep-layer neurons in dmFrC most strongly represented the reward-predicting cue and recent reward history. Our results suggest that these neurons ignite the cortical processes required to select appropriate actions.