Microglia-Müller cell interactions in the retina.
Microglia-Müller cell interactions in the retina.
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DOI：
10.1007/978-1-4614-3209-8_42
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发表时间：
2014
影响因子：
--
通讯作者：
Wong WT
中科院分区：
文献类型：
--
作者：
Wang M;Wong WT
小胶质细胞和Müller细胞是对视网膜中的疾病和损伤做出反应的突出细胞类型。然而，它们之间的相互作用尚未被详细研究。在这里，我们回顾的证据表明，这两个细胞群交换功能显着的信号在未受伤的条件下，在视网膜炎症。在正常情况下，Müller细胞构成了细胞外ATP的潜在来源，其介导小胶质细胞动态过程运动的活性依赖性调节。在炎症中小胶质细胞活化后，小胶质细胞可以向Müller细胞发出信号，影响它们的形态、分子和功能反应。小胶质细胞-Müller细胞相互作用似乎是一种双向通信模式，有助于形成视网膜中的整体损伤反应。
Microglia and Müller cells are cell types that feature prominently in responses to disease and injury in the retina. However, their mutual interactions have not been investigated in detail. Here, we review evidence that indicate that these two cell populations exchange functionally significant signals under uninjured conditions and during retinal inflammation. Under normal conditions, Müller cells constitute a potential source of extracellular ATP that mediates the activity-dependent regulation of microglial dynamic process motility. Following microglial activation in inflammation, microglia can signal to Müller cells, influencing their morphological, molecular, and functional responses. Microglia-Müller cell interactions appear to be a mode of bi-directional communications that help shape the overall injury response in the retina.