AUTOANTIBODY AGAINST OXIDIZED LDL AND PROGRESSION OF CAROTID ATHEROSCLEROSIS
AUTOANTIBODY AGAINST OXIDIZED LDL AND PROGRESSION OF CAROTID ATHEROSCLEROSIS
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DOI：
10.1016/0140-6736(92)90926-t
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发表时间：
1992-04-11
期刊：
影响因子：
168.9
通讯作者：
WITZTUM, JL
中科院分区：
文献类型：
--
作者：
SALONEN, JT;YLAHERTTUALA, S;WITZTUM, JL
LDL 的氧化修饰使其具有免疫原性，并且针对氧化 LDL 表位（如丙二醛 (MDA) -赖氨酸）的自身抗体存在于血清中并识别动脉粥样硬化组织中的物质。然而，目前还没有前瞻性研究来评估氧化 LDL 在血管疾病患者中的重要性。我们比较了 30 名颈动脉粥样硬化两年加速进展的芬兰东部男性和 30 名年龄匹配的无进展对照者的基线血清样本中自身抗体与 MDA 修饰 LDL 和天然 LDL 的滴度。两组均没有与天然 LDL 结合的特异性抗体。滴度定义为抗体与MDA-LDL结合/与天然LDL结合的比率。病例的 MDA-LDL 滴度明显较高（2.67 vs 2.06，p = 0.003）。病例中吸烟者比例较高（37% vs 3%），LDL 胆固醇较高（4.2 mmol/l vs 3.6 mmol/l），血清铜浓度较高（1.14 mg/l vs 1.04 mg/l）。即使在调整了这些变量和基线动脉粥样硬化的严重程度后，多因素逻辑模型中抗体滴度的差异仍然显着 (p = 0.031)。因此，MDA-LDL 自身抗体的滴度是这些芬兰男性颈动脉粥样硬化进展的独立预测因子。我们的数据进一步支持氧化修饰的低密度脂蛋白在动脉粥样硬化形成中的作用。
Oxidative modification of LDL renders it immunogenic and autoantibodies to epitopes of oxidised LDL, such as malondialdehyde (MDA) -lysine, are found in serum and recognise material in atheromatous tissue. However, there has been no prospective study to assess the importance of oxidised LDL among patients with vascular disease.We compared the titre of autoantibodies to MDA-modified LDL and native LDL in baseline serum samples of 30 eastern Finnish men with accelerated two-year progression of carotid atherosclerosis and 30 age-matched controls without progression. Neither group had specific antibody binding to native LDL. A titre was defined as a ratio of antibody binding to MDA-LDL/binding to native LDL. Cases had a significantly higher titre to MDA-LDL (2.67 vs 2.06, p = 0.003). Cases also had a greater proportion of smokers (37% vs 3%), higher LDL cholesterol (4.2 mmol/l vs 3.6 mmol/l), and higher serum copper concentration (1.14 mg/l vs 1.04 mg/l). Even after adjusting for these variables and the severity of baseline atherosclerosis, the difference in antibody titre remained significant in a multifactorial logistic model (p = 0.031).Thus, the titre of autoantibodies to MDA-LDL was an independent predictor of the progression of carotid atherosclerosis in these Finnish men. Our data provide further support for a role of oxidatively modified LDL in atherogenesis.