Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease.
Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease.
复制标题
莱姆病自然流行周期和发展过程中的螺旋体运动和趋化作用。
DOI：
10.1016/j.mib.2015.09.006
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发表时间：
2015-12
影响因子：
5.4
通讯作者：
Wooten RM
中科院分区：
文献类型：
--
作者：
Motaleb MA;Liu J;Wooten RM
迄今为止测序的所有细菌基因组中有三分之二具有用于运动的细胞器，称为鞭毛、周质鞭毛或IV型皮利。这些基因组还可能包含趋化性信号系统，该系统控制鞭毛旋转，从而导致运动的协调功能。运动性和趋化性在病原菌引起的感染或疾病过程中起着至关重要的作用。尽管运动相关基因在某些生物中已得到很好的表征，但螺旋体中周质鞭毛的高度协调的合成、调节和组装才刚刚被描绘出来。螺旋体独特的遗传操作加上尖端的成像技术的发展促进了最近的进展。这些当代的进展，了解螺旋体的运动和趋化性在宿主的持久性和疾病的发展中的作用，强调在这方面的审查。
Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili. These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility. Motility and chemotaxis are often crucial for infection or disease process caused by pathogenic bacteria. Although motility-associated genes are well-characterized in some organisms, the highly-orchestrated synthesis, regulation, and assembly of periplasmic flagella in spirochetes are just being delineated. Recent advances were fostered by development of unique genetic manipulations in spirochetes coupled with cutting-edge imaging techniques. These contemporary advances in understanding the role of spirochetal motility and chemotaxis in host persistence and disease development are highlighted in this review.