MACROPHAGE ACTIVATION BY LACTOBACILLUS-CASEI IN MICE
MACROPHAGE ACTIVATION BY LACTOBACILLUS-CASEI IN MICE
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DOI：
10.1111/j.1348-0421.1983.tb00622.x
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发表时间：
1983-01-01
影响因子：
2.6
通讯作者：
MUTAI, M
中科院分区：
文献类型：
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作者：
KATO, I;YOKOKURA, T;MUTAI, M
L.研究了对同种异体和同系小鼠肿瘤具有抗肿瘤活性的caseiYIT 9018（LC 9018）对巨噬细胞功能的影响。腹腔注射LC 9018后，腹腔巨噬细胞的酸性磷酸酶活性和吞噬活性明显增强。吞噬活性在注射LC 9018后2-3天出现高峰。LC 9018对ICR小鼠RES的吞噬功能有明显的促进作用。腹腔注射LC 9018诱导的C57 BL/6小鼠腹腔渗出液细胞（PEC）对[小鼠白血病] EL 4细胞的抑制活性也增强。L.无抗肿瘤活性的发酵菌YIT 0159不具有细胞抑制活性。这些观察结果表明LC 9018能够激活小鼠中的巨噬细胞。
Effects of L. casei YIT 9018 (LC 9018), which has antitumor activities against allogeneic and syngeneic murine tumors, on macrophage functions were examined. By i.p. injection of LC 9018, acid phosphatase activity and phagocytic activity of peritoneal macrophages were enhanced significantly compared with those of normal peritoneal macrophages. The phagocytic activities showed peaks 2-3 days after the LC 9018-injection. LC 9018 accelerated the phagocytic function of the RES in ICR mice tested by the carbon clearance test. The cytostatic activity of peritoneal exudate cells (PEC) induced by i.p. injection of LC 9018 into C57BL/6 mice against [mouse leukemia] EL4 cells was also enhanced. PEC induced by L. fermentum YIT 0159, which has no antitumor activity, did not have cytostatic activity. These observations showed that LC 9018 was able to activate macrophages in mice.