Effects of the essential oil constituent thymol and other neuroactive chemicals on flight motor activity and wing beat frequency in the blowfly Phaenicia sericata.
Effects of the essential oil constituent thymol and other neuroactive chemicals on flight motor activity and wing beat frequency in the blowfly Phaenicia sericata.
复制标题
精油成分百里香酚和其他神经活性化学物质对绿蝇雉鸡飞行运动活动和翅膀拍动频率的影响。
DOI：
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发表时间：
2010
影响因子：
4.1
通讯作者：
C. Lowenberger
中科院分区：
文献类型：
--
作者：
Ranil Waliwitiya;P. Belton;R. Nicholson;C. Lowenberger
背景
评价了植物萜类百里酚和其他8种神经活性化合物对被拴系的丝光绿蝇（Phaenicia sericata Meig.）的飞行肌冲动（FMIs）和翅拍频率（WBF）的影响。
结果
背长飞行肌的电活动与对照昆虫的WBF密切相关。局部应用百里酚在15-30分钟内抑制WBF并降低FMI频率。章鱼胺和杀虫脒引起了类似的，早发性爆裂模式，随着时间的推移，幅度下降。二甲杀虫脒在60分钟内阻断了翅膀的跳动，并产生了连续但频率较低的FMIs。氟虫腈抑制翅膀跳动，并诱导一种连续的，可变频率的尖峰，逐渐减少超过6小时。氯氰菊酯和鱼藤酮处理过的苍蝇最初有很强的FMI，随着时间的推移而下降。在注射GABA的果蝇中，FMI通常是单向的，频率降低，与百里酚一样。
结论
麝香草酚很容易穿透角质层，干扰苍蝇的飞行肌肉和中枢神经功能。百里酚和GABA的作用的相似性表明，这种萜类化合物通过模仿或促进GABA的作用集中在绿头苍蝇中起作用。
BACKGROUND
The effects were evaluated of the plant terpenoid thymol and eight other neuroactive compounds on flight muscle impulses (FMIs) and wing beat frequency (WBF) of tethered blowflies (Phaenicia sericata Meig.).
RESULTS
The electrical activity of the dorsolongitudinal flight muscles was closely linked to the WBF of control insects. Topically applied thymol inhibited WBF within 15-30 min and reduced FMI frequency. Octopamine and chlordimeform caused a similar, early-onset bursting pattern that decreased in amplitude with time. Desmethylchlordimeform blocked wing beating within 60 min and generated a profile of continuous but lower-frequency FMIs. Fipronil suppressed wing beating and induced a pattern of continuous, variable-frequency spiking that diminished gradually over 6 h. Cypermethrin- and rotenone-treated flies had initial strong FMIs that declined with time. In flies injected with GABA, the FMIs were generally unidirectional and frequency was reduced, as was seen with thymol.
CONCLUSIONS
Thymol readily penetrates the cuticle and interferes with flight muscle and central nervous function in the blowfly. The similarity of the action of thymol and GABA suggests that this terpenoid acts centrally in blowflies by mimicking or facilitating GABA action.
甲脒杀虫剂和 α2-肾上腺素受体：大鼠体内双甲脒和杀虫脒的研究以及放射性受体结合测定的开发。
影响因子：
2.9
作者：
Costa,LG;Wu,DS;Olibet,G;Murphy,SD
通讯作者：
Murphy,SD