Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan
Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan
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DOI：
10.1016/j.jep.2015.03.047
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发表时间：
2015-06-20
影响因子：
5.4
通讯作者：
Chu, Yen-Hua
中科院分区：
文献类型：
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作者：
Chu, Shih-Meng;Shih, Wei-Tai;Chu, Yen-Hua
民族-药理学相关性：中草药产品(CHPs)通常用于中医高脂血症患者。由于高脂血症及相关疾病是世界范围内的常见问题，本研究分析了台湾地区高脂血症患者CHP的处方模式和使用频率。背景：中医药已成为控制高脂血症患者症状的一种流行疗法。本研究旨在分析台湾地区高脂血症患者的中医药处方模式。方法：从2003-2009年间国家医疗保险研究数据库中随机抽取100万人作为研究对象。我们确定了30784次与高脂血症诊断相关的门诊就诊，并收集了这些医疗记录。结果：治疗高脂血症最常用的中药配方为血府逐瘀汤(16.1%)，山茶(山楂；25.0%)是最常用的单味药。中草药与单味药配伍最多的是血府逐瘀汤和丹参，最常配伍的是丹参和山寨。结论：血府逐瘀汤是高脂血症患者最常用的方剂，一般与山茶、丹参、和寿乌配伍。在未来的研究中，有必要进行临床试验，以调查CHP在安全性和有效性方面的效果，特别是评估与传统治疗的潜在相互作用。(C)爱思唯尔爱尔兰有限公司出版的2015年。
Ethno-pharmacological relevance: Chinese herbal products (CHPs) are commonly used in patients with hyperlipidemia in traditional Chinese medicine (TCM). Because hyperlipidemia and related disease are common issues worldwide, this study analyzed the prescription patterns and frequencies of CHPs for treating patients with hyperlipidemia in Taiwan.Background: Traditional Chinese medicine (TCM) has become popular as a therapy for controlling symptoms in patients with hyperlipidemia. This study aimed to analyze the prescription patterns of TCM for patients with hyperlipidemia in Taiwan.Methods: The study population was recruited from a random-sampled cohort of 1,000,000 people from the National Health Insurance Research Database between 2003 and 2009. We identified 30,784 outpatient visits related with hyperlipidemia diagnosis and collected these medical records. Association rules of data mining were conducted to explore the co-prescription patterns for Chinese herbal products (CHPs).Results: The most commonly prescribed herbal formula for hyperlipidemia treatment was Xue-Fu-ZhuYu-Tang (16.1%), and Shan Zha (Crataegi fnictus; 25.0%) was the most commonly prescribed single herb. The most commonly prescribed combination of an herbal formula and a single herb was Xue-Fu-Zhu-Yu-Tang and Dan Shen (Radix Salviae Miltiorrhizae), and the most commonly prescribed combination of couplet herbs was Dan Shen and Shan Zha.Conclusion: Xue-Fu-Zhu-Yu-Tang is the most frequently prescribed formula and is typically prescribed with Shan Zha, Dan Shen, and He Shou Wu for patients with hyperlipidemia. Clinical trials are warranted in future research to investigate the effects of the CHPs in terms of safety and efficacy and in particular to evaluate potential interactions with conventional treatments. (C) 2015 Published by Elsevier Ireland Ltd.