Prone accelerated partial breast irradiation after breast-conserving surgery: Preliminary clinical results and dose-volume histogram analysis
Prone accelerated partial breast irradiation after breast-conserving surgery: Preliminary clinical results and dose-volume histogram analysis
复制标题
DOI：
10.1016/j.ijrobp.2004.04.036
复制
发表时间：
2004-10-01
影响因子：
7
通讯作者：
Dewyngaert, JK
中科院分区：
文献类型：
--
作者：
Formenti, SC;Truong, MT;Dewyngaert, JK
目的：报告加速部分乳腺照射方案前47例患者的临床和剂量体积直方图结果。患者在俯卧位进行三维适形放射治疗后，乳腺癌保surgery.Methods和Materials：绝经后妇女T1 N 0期乳腺癌有资格后，他们首先拒绝接受6周的标准放疗。在专用检查床上进行俯卧位计划CT。术后腔被定义为临床靶体积，增加1.5 cm边缘以确定计划靶体积。总剂量为30戈伊，6戈伊/次，在10天内分5次提供。结果：患者的中位年龄为67.5岁（范围，51-88岁）。中位肿瘤直径为9 mm（范围，1.3-19 mm）。在所有患者中，处方剂量涵盖计划靶体积。接受100%处方剂量的同侧乳房的平均体积为26%（范围，10-45%），50%等剂量表面内包含的平均体积为47%（范围，23-75%）。采用俯卧位治疗，肺和心脏得以保留。急性毒性为中度，主要限于1-2级红斑。中位随访18个月，只有I级晚期毒性发生，没有病人发生局部recurrence.Conclusion：这些数据表明，这种方法是耐受性良好的，只有轻微的急性副作用和保留的心脏和肺。(C)2004年爱思唯尔公司
Purpose: To report the clinical and dose-volume histogram results of the first 47 patients accrued to a protocol of accelerated partial breast irradiation. Patients were treated in the prone position with three-dimensional conformal radiotherapy after breast-conserving surgery.Methods and Materials: Postmenopausal women with Stage T1N0 breast cancer were eligible only after they had first refused to undergo 6 weeks of standard radiotherapy. Planning CT in the prone position was performed on a dedicated table. The postoperative cavity was defined as the clinical target volume, with a 1.5-cm margin added to determine the planning target volume. A total dose of 30 Gy at 6 Gy/fraction was delivered in five fractions within 10 days.Results: The median age of the patients was 67.5 years (range, 51-88 years). The median tumor diameter was 9 mm (range, 1.3-19 mm). In all patients, the prescribed dose encompassed the planning target volume. The mean volume of the ipsilateral breast receiving 100% of the prescription dose was 26% (range, 10-45%), and the mean volume contained within the 50% isodose surface was 47% (range, 23-75%). The lung and heart were spared by treating in the prone position. Acute toxicity was modest, limited mainly to Grade 1-2 erythema. With a median follow-up of 18 months, only Grade I late toxicity occurred, and no patient developed local recurrence.Conclusion: These data suggest that this approach is well tolerated, with only mild acute side effects and sparing of the heart and lung. (C) 2004 Elsevier Inc.