Comparing the organophosphorus and carbamate insecticide resistance mutations in cholin- and carboxyl-esterases
Comparing the organophosphorus and carbamate insecticide resistance mutations in cholin- and carboxyl-esterases
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DOI：
10.1016/j.cbi.2005.10.041
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发表时间：
2005-12-15
影响因子：
5.1
通讯作者：
Russell, RJ
中科院分区：
文献类型：
--
作者：
Oakeshott, JG;Devonshire, AL;Russell, RJ
昆虫羧基/胆碱酯酶突变是 60 多例对有机磷和/或氨基甲酸酯杀虫剂产生抗性的原因。其中约 20 个的生化和分子数据显示，反复使用极少量的突变选项来产生靶位点或代谢抗性。此外，由于酶原始功能的性能受损，突变酶通常在动力学上效率低下，并且与显着的适应性成本相关。相比之下，现在已知许多细菌酶可以有效地解毒这些农药。过去 60 年来，遗传密码和真核生物遗传系统的限制似乎严重限制了昆虫对杀虫剂广泛使用的进化反应。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Mutant insect carboxyl/cholinesterases underlie over 60 cases of resistance to organophosphorus and/or carbarnate insecticides. Biochemical and molecular data on about 20 of these show recurrent use of a very small number of mutational options to generate either target site or metabolic resistance. Moreover, the mutant enzymes are often kinetically inefficient and associated with significant fitness costs, due to impaired performance of the enzymes' original function. By contrast many bacterial enzymes are now known which can effectively detoxify these pesticides. It appears that the constraints of the genetic code and eukaryote genetic systems have severely limited the evolutionary response of insects to the widespread use of the insecticides over the last 60 years. (c) 2005 Elsevier Ireland Ltd. All rights reserved.