Localization of TFF3, a new mucus-associated peptide of the human respiratory tract
Localization of TFF3, a new mucus-associated peptide of the human respiratory tract
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DOI：
10.1164/ajrccm.159.4.9804149
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发表时间：
1999-04-01
影响因子：
24.7
通讯作者：
Hoffmann, W
中科院分区：
文献类型：
--
作者：
Wiede, A;Jagla, W;Hoffmann, W
三叶因子家族（TFF）-结构域肽（以前称为P-结构域肽，三叶因子）是胃肠道中主要的粘蛋白相关肽。免疫组化显示TFF 3在粘膜下腺体的腺泡中的粘液细胞中显著积累，并且在小管部分和表面上皮的杯状细胞中有不同的量。TFF 3也作为粘液的一种成分出现，例如来自慢性支气管炎患者。TFF 3的表达也通过使用聚合酶链反应显示。相反，TFF 1和TFF 2转录物在人呼吸道中几乎检测不到。因此，TFF 3的气道粘液的结构功能进行了讨论，可能与粘蛋白MUC 5 B和MUC 5AC。
Trefoil factor family (TFF)-domain peptides (formerly P-domain peptides, trefoil factors) represent major mucin-associated peptides of the gastrointestinal tract, Here, the first localization studies on TFR in the lower respiratory tract of human material are presented. Immunohistochemistry revealed significant accumulation of TFF3 to mucous cells in the acini of submucosal glands and varying amounts in goblet cells at the ductular portions and the surface epithelium. TFF3 appears also as a component of the mucus, for example from patients with chronic bronchitis. Expression of TFF3 was also shown by use of the polymerase chain reaction. In contrast, TFF1 and TFF2 transcripts were hardly detectable in the human respiratory tract. Thus, a structural function of TFF3 for the airway mucus is discussed, possibly together with the mucins MUC5B and MUC5AC.