Intergenerational transmission of subthreshold autistic traits in the general population
Intergenerational transmission of subthreshold autistic traits in the general population
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DOI：
10.1016/j.biopsych.2004.12.014
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发表时间：
2005-03-15
影响因子：
10.6
通讯作者：
Todd, RD
中科院分区：
文献类型：
--
作者：
Constantino, JN;Todd, RD
背景：自闭症（AD）是一种致残的多基因疾病，其特征是严重的社交障碍。已知亚阈值自闭症社交障碍在自闭症先证者的家庭成员中聚集；因此，我们进行这项研究以检验此类特征在普通人群中的代际传递情况。
方法：社交反应量表（SRS）是一种自闭症特征的定量测量工具，由母亲报告完成了285对双胞胎的测量，由配偶报告完成了其父母的测量。
结果：父母与子女之间以及配偶之间社交障碍或能力的相关性约为0.4。在父母双方在SRS社交障碍量表中得分都处于上四分位数的家庭中，后代的平均SRS得分显著升高（效应量为1.5）。估计的选型婚配解释了父母SRS得分变异的约30%。
结论：父母双方都表现出亚阈值自闭症特征的家庭中的儿童，其在相互社交行为障碍得分的分布上朝着病理端有显著偏移。正如先前在儿童中所证明的那样，可遗传的亚阈值自闭症障碍在成年人中是可测量的，并且在普通人群中呈连续分布。
Background: Autistic disorder (AD) is a disabling oligogenic condition characterized by severe social impairment. Subthreshold autistic social impairments are known to aggregate in the family members of autistic probands; therefore, we conducted this study to examine the intergenerational transmission of such traits in the general population.Methods: The Social Responsiveness Scale (SRS), a quantitative measure of autistic traits, was completed on 285 pairs of twins (by maternal report) and on their parents (by spouse report).Results: Correlation for social impairment or competence between parents and their children and between spouses was on the order of 4. In families in which both parents scored in the upper quartile for social impairment on the SRS, mean SRS score of offspring was significantly elevated (effect size 1.5). Estimated assortative mating explained approximately 30% of the variation in parent SRS scores.Conclusions: Children from families in which both parents manifest subthreshold autistic traits exhibit a substantial shift in the distribution of their scores for impairment in reciprocal social behavior, toward the pathological end. As has been previously demonstrated in children, heritable subthreshold autistic impairments are measurable in adults and appear continuously distributed in the general population.