Ginseng berry reduces blood glucose and body weight in db/db mice
Ginseng berry reduces blood glucose and body weight in db/db mice
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DOI：
10.1078/0944-7113-00106
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发表时间：
2002-04-01
期刊：
影响因子：
7.9
通讯作者：
Yuan, CS
中科院分区：
文献类型：
--
作者：
Xie, JT;Zhou, YP;Yuan, CS
在本研究中，我们观察了人参莓对C57BL/Ks db/db成年小鼠及其瘦仔鼠的抗糖尿病和抗肥胖作用。每天腹腔注射人参浆果提取物150 mg/kg体重，连续12天。第5天，经提取物处理的db/db小鼠的空腹血糖水平显著低于对照组（180.5 +/- 10.2 mg/dl vs. 226.0 +/- 15.3 mg/dl, P < 0.01）。第12天，提取液处理的db/db小鼠血糖正常（134.3 +/- 7.3 mg/dl），而对照组小鼠血糖正常（254.8 +/- 24.1 mg/dl, P < 0.01）。精瘦小鼠的空腹血糖水平在提取物处理后没有明显降低。给药12 d后，葡萄糖耐量显著增加，以曲线下面积（AUC）计算的总血糖暴露量（db/db）降低53.4% （P < 0.01）。此外，与第0天相比，150 mg/kg体质量的db/db小鼠体重从第0天的51.0 +/- 1.9 g下降到第5天的46.6 +/- 1.7 g，第12天的45.2 +/- 1.4 g（分别P < 0.05和P < 0.01）。在相同剂量的提取物下，瘦仔鼠的体重也有所下降。提示人参提取物对糖尿病和肥胖患者有一定的治疗价值。
In this study, we observed anti-diabetic and anti-obesity effects of Panax ginseng berry in adult C57BL/Ks db/db mice and their lean littermates. Animals received daily intraperitoneal injections of Panax ginseng berry extract at 150 mg/kg body wt. for 12 consecutive days. On Day 5, the extract-treated db/db mice had significantly lower fasting blood glucose levels as compared to vehicle-treated mice (180.5 +/- 10.2 mg/dl vs. 226.0 +/- 15.3 mg/dl, P < 0.01). On day 12, the extract-treated db/db mice were normoglycemic (134.3 +/- 7.3 mg/dl) as compared to vehicle-treated mice (254.8 +/- 24.1 mg/dl; P < 0.01). Fasting blood glucose levels of lean mice did not decrease significantly after treatment with extract. After 12 days of treatment with the extract, glucose tolerance increased significantly, and overall blood glucose exposure calculated as area under the curve (AUC) decreased 53.4% (P < 0.01) in db/db mice. Furthermore, db/db mice treated with extract (150 mg/kg body wt.) showed weight loss from 51.0 +/- 1.9 g on Day 0, to 46.6 +/- 1.7 g on Day 5, and to 45.2 +/- 1.4 g on Day 12 (P < 0.05 and P < 0.01 compared to Day 0, respectively). The body weight of lean littermates also decreased at the same dose of extract. These data suggest that Panax ginseng berry extract may have therapeutic value in treating diabetic and obese patients.