Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence
Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence
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牙周炎与房颤消融的结果：牙龈卟啉单胞菌与房颤复发相关
DOI：
10.1111/jce.14952
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发表时间：
2021
影响因子：
2.7
通讯作者：
Nakano Yukiko
中科院分区：
文献类型：
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作者：
Miyauchi Shunsuke;Tokuyama Takehito;Shintani Tomoaki;Nishi Hiromi;Hamamoto Yuta;Ouhara Kazuhisa;Furusho Hisako;Miyauchi Mutsumi;Komatsuzawa Hitoshi;Nakano Yukiko
炎症是心房颤动（AF）消融后复发的主要原因之一。牙龈卟啉单胞菌是口腔-全身疾病中重要的牙周病原体，血清抗卟啉单胞菌免疫球蛋白G （IgG）抗体滴度。牙龈炎反映牙周炎的临床状况。本研究旨在探讨射频导管消融（RFCA）后房颤晚期复发与血清抗stp IgG抗体滴度的关系。gingivalis。方法596例房颤患者（平均年龄64.9±10.0岁，男性69%，阵发性房颤61%）首次行RFCA治疗。在平均17.1±14.5个月的随访期间，仔细检查患者是否有晚期复发。血清抗stp IgG抗体滴度。采用酶联免疫吸附法检测牙龈炎（I-IV型）。血清抗体滴度结果分为高值组和低值组。结果：在五个p。牙龈病毒亚型，血清抗stp抗体滴度。gingivalistype IV与晚期复发相关（优势比1.937；95%可信区间[CI]， 1.301-2.884;p= 0.002）。多因素Cox比例风险回归分析显示血清抗stp抗体滴度高。gingivalisttype IV独立预测晚期复发（阵发性房颤：校正风险比[HR] 1.569; 95% CI, 1.010-2.427;p= 0.04；非阵发性房颤：校正风险比，1.909;95% CI, 1.213-3.005;p= 0.004）。结论牙周炎与心房颤动术后晚期复发有关。IV型龈型可能是心房颤动术后复发的致病因素。
IntroductionInflammation is one of the main causes of atrial fibrillation (AF) recurrence after ablation.Porphyromonas gingivalisis a key periodontal pathogen in the oral–systemic disease connection and serum immunoglobulin G (IgG) antibody titers againstP. gingivalisreflect the clinical status of periodontitis. This study aimed to investigate the relationship between late recurrence of AF after radiofrequency catheter ablation (RFCA) and serum IgG antibody titers againstP. gingivalis.MethodsA total of 596 AF patients (mean age, 64.9 ± 10.0 years; 69% male; 61% paroxysmal AF) who underwent a first session of RFCA were enrolled. Patients were carefully examined for late recurrence during a mean follow‐up period of 17.1 ± 14.5 months. Serum IgG antibody titers againstP. gingivalis(types I–IV) were measured using enzyme‐linked immunosorbent assay. The results of serum antibody titers were divided into a high‐value and a low‐value group.ResultsAmong the fiveP. gingivalissubtypes, serum antibody titer againstP. gingivalistype IV was associated with late recurrence (odds ratio, 1.937; 95% confidence interval [CI], 1.301–2.884;p= .002). Multivariate Cox proportional‐hazards regression analysis revealed that high‐value serum antibody titer againstP. gingivalistype IV independently predicted late recurrence (paroxysmal AF: adjusted hazard ratio [HR], 1.569; 95% CI, 1.010–2.427;p= .04; non‐paroxysmal AF: adjusted HR, 1.909; 95% CI, 1.213–3.005;p= .004).ConclusionPeriodontitis was related to the late recurrence of AF after RFCA.P. gingivalistype IV may be pathogenic for AF recurrence after RFCA.