The panspecific hemopoietin of activated T lymphocytes (interleukin-3).
The panspecific hemopoietin of activated T lymphocytes (interleukin-3).
复制标题
活化 T 淋巴细胞的泛特异性造血素（白细胞介素 3）。
DOI：
10.1146/annurev.iy.04.040186.001225
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发表时间：
1986
影响因子：
29.7
通讯作者：
Schrader,JW
中科院分区：
文献类型：
--
作者：
Schrader,JW
细胞技术、生化技术和重组DNA技术的结合应用，使人们对PSH和其他一些T细胞淋巴因子的分子结构有了一个相对清晰的了解。已经有证据表明，新的技术，特别是生物活性多肽的化学合成，将迅速导致对PSH及其活性部位的二级和三级结构的详细描述。此外，受体抗体的可获得性和重组DNA技术的使用应导致对细胞表面受体的分子表征，并最终对其与PSH的相互作用进行详细的结构分析。鉴于PSH可能在慢性过敏性疾病中发挥关键作用，也可能在血液系统疾病中发挥关键作用，PSH的类似物和拮抗剂可能为这些疾病的新治疗方法提供基础。
The combined deployment of cellular, biochemical, and recombinant DNA techniques has resulted in the emergence of a relatively clear picture of the molecular structure of PSH and of a number of other T-cell lymphokines. Already there is evidence that new techniques, in particular, the chemical synthesis of biologically active peptides, will lead rapidly to a detailed picture of the secondary and tertiary structure of PSH and its active sites. Moreover, the availability of antibodies to the receptor and the use of recombinant DNA techniques should result in the molecular characterization of the cell-surface receptor and eventually a detailed structural analysis of its interaction with PSH. Given the likelihood that PSH may play a pivotal role in chronic allergic diseases and possibly in hematological disorders, there are real prospects that analogues and antagonists of PSH may provide a basis for new therapeutic approaches to these diseases.