The HUPO proteomics standards initiative - Overcoming the fragmentation of proteomics data
The HUPO proteomics standards initiative - Overcoming the fragmentation of proteomics data
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DOI：
10.1002/pmic.200600537
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发表时间：
2006-09-01
期刊：
影响因子：
3.4
通讯作者：
Hermjakob, Henning
中科院分区：
文献类型：
--
作者：
Hermjakob, Henning
蛋白质组学是现代生物分子研究的一个关键领域，许多小型和大规模的努力产生了丰富的蛋白质组学数据，然而，绝大多数这些数据从未充分利用其潜力。即使在公共资助的项目中，通常也会对特定背景下产生的原始数据进行分析，得出结论并发表，但很少注意系统地记录、存档和公众获取支持科学结果的数据。通常很难验证特定出版物中所述的结果，甚至像“我感兴趣的蛋白质在哪种细胞环境中被观察到？”这样简单的全球性问题，由于缺乏标准化的蛋白质组学数据报告和收集，目前也无法通过现实的努力来回答。蛋白质组学标准倡议（PSI）是人类蛋白质组学组织（HUPO）的一个工作组，它定义了蛋白质组学数据表示的社区标准，以促进系统的数据捕获、比较、交换和验证。在本文中，我们概述了PSI的组织结构、活动和当前结果，以及参与广泛开放的PSI过程的方法。
Proteomics is a key field of modern biomolecular research, with many small and large scale efforts producing a wealth of proteomics data However, the vast majority of this data is never exploited to its full potential. Even in publicly funded projects, often the raw data generated in a specific context is analysed, conclusions are drawn and published, but little attention is paid to systematic documentation, archiving, and public access to the data supporting the scientific results. It is often difficult to validate the results stated in a particular publication, and even simple global questions like "In which cellular contexts has my protein of interest been observed?" can currently not be answered with realistic effort, due to a lack of standardised reporting and collection of proteomics data.The Proteomics Standards Initiative (PSI), a work group of the Human Proteome Organisation (HUPO), defines community standards for data representation in proteomics to facilitate systematic data capture, comparison, exchange and verification. In this article we provide an overview of PSI organisational structure, activities, and current results, as well as ways to get involved in the broad-based, open PSI process.