Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy
Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy
复制标题
叶酸共轭二氧化硅修饰的金纳米棒用于 X 射线/CT 成像引导的双模辐射和光热治疗
DOI：
10.1016/j.biomaterials.2011.08.086
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发表时间：
2011-12-01
期刊：
影响因子：
14
通讯作者：
Cui, Daxiang
中科院分区：
文献类型：
--
作者：
Huang, Peng;Bao, Le;Cui, Daxiang
多功能纳米探针被设计成具有多种功能，如肿瘤靶向，成像和选择性治疗，这为癌症的预防，诊断，成像和治疗的未来提供了巨大的希望。采用Stober法将十六烷基三甲基溴化铵（CTAB）分子修饰在金纳米棒（GNRs）表面，以消除GNRs的细胞毒性，提高GNRs的生物相容性。用硅烷偶联剂将叶酸分子共价锚定在GNRs表面。所得到的叶酸缀合的二氧化硅修饰的GNRs显示出对MGC 803胃癌细胞的高度选择性靶向、增强的放射治疗（RT）和光热治疗（PTT）效果，并且对于体内X射线和计算机断层扫描（CT）成像也表现出强的X射线衰减。总之，所制备的纳米探针是具有优异的成像和靶向能力的良好候选物，用于X射线/CT成像引导靶向双模式增强RT和PTT。(C)2011爱思唯尔有限公司保留所有权利。
Multifunctional nanoprobes are designed to own various functions such as tumor targeting, imaging and selective therapy, which offer great promise for the future of cancer prevention, diagnosis, imaging and treatment. Herein, silica was applied to replace cetyltrimethylammonium bromide (CTAB) molecules on the surface of gold nanorods (GNRs) by the classic Stober method, thus eliminating their cytotoxicity and improving their biocompatibility. Folic acid molecule was covalently anchored on the surface of GNRs with silane coupling agent. The resultant folic acid-conjugated silica-modified GNRs show highly selective targeting, enhanced radiation therapy (RT) and photo-thermal therapy (PTT) effects on MGC803 gastric cancer cells, and also exhibited strong X-ray attenuation for in vivo X-ray and computed tomography (CT) imaging. In conclusion, the as-prepared nanoprobe is a good candidate with excellent imaging and targeting ability for X-ray/CT imaging-guided targeting dual-mode enhanced RT and PTT. (C) 2011 Elsevier Ltd. All rights reserved.