Tissue-engineered bone grafts for osteoplasty in patients with cleft alveolus
Tissue-engineered bone grafts for osteoplasty in patients with cleft alveolus
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DOI：
10.1016/j.aanat.2012.06.002
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发表时间：
2012-01-01
影响因子：
2.2
通讯作者：
Lauer, Guenter
中科院分区：
文献类型：
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作者：
Pradel, Winnie;Lauer, Guenter
牙槽骨移植是腭裂患者治疗理念的一个组成部分。作为自体骨的替代物，组织工程化骨移植物已获得一定的临床应用。本研究的目的是比较使用组织工程移植物在牙槽骨成形术中移植自体海绵骨作为金标准后骨化的患者的病例系列中在牙槽骨裂区域的骨化。八名完全性唇裂和腭裂儿童被纳入研究。A组4例，采用组织工程骨（脱钙骨基质Osteovit（R）上培养的自体成骨细胞）填充裂隙缺损; B组4例，采用松质髂骨进行牙槽骨成形术作为对照。术前和术后6个月进行锥形束计算机断层扫描，并使用3D导航软件计算剩余裂隙缺损的体积。两组的伤口愈合均顺利。术后6个月，组织工程骨（A组）移植后裂隙的平均体积为0.55 +/- 0.24cm（3），自体松质骨移植后裂隙的平均体积为0.59 +/- 0.23cm（3）。对照组（B组）36.6%，A组40.9%。组织工程骨是牙槽骨移植的一种很有前途的替代方法，与金标准相比，没有观察到任何缺点。(c)2012 Elsevier GmbH. All rights reserved.
Alveolar bone grafting is an integral part of the treatment concept in cleft palate patients. As an alternative to autogenous bone, tissue-engineered grafts have found some clinical application. The aim of the present study has been to compare ossification in the cleft area using tissue-engineered grafts in a case series of patients with ossification after transplantation of autogenous spongious bone as the gold standard in alveoloplasty. Eight children with complete cleft lips and cleft palates were included in the study. In four children (group A), the cleft defect was filled with tissue-engineered bone (autogenous osteoblasts cultured on demineralized bone matrix Osteovit (R)); as control in another 4 children (group B), the alveoloplasty was performed using spongious iliac bone. Preoperative and 6 months postoperative cone-beam computed tomography was performed, and volumes of the remaining cleft defects were calculated using 3D navigation software. Wound healing was uneventful in both groups. Six months post-operatively the mean volume of the cleft was 0.55 +/- 0.24cm(3) after grafting of tissue-engineered bone (group A) and 0.59 +/- 0.23cm(3) after transplantation of autogenous spongiosa. In group A, 40.9% of the cleft defect was ossified; in the control group (group B), 36.6%. Tissue-engineered bone is a promising alternative in alveolar bone grafting and no disadvantages were observed in comparison to the gold standard. (c) 2012 Elsevier GmbH. All rights reserved.