Epstein-Barr virus positivity in primary vaginal lymphoma.
Epstein-Barr virus positivity in primary vaginal lymphoma.
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原发性阴道淋巴瘤中 Epstein-Barr 病毒阳性。
DOI：
10.1016/j.ygyno.2004.08.048
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发表时间：
2004
影响因子：
4.7
通讯作者：
A. Pellicer
中科院分区：
文献类型：
--
作者：
S. Domingo;A. Perales;V. Torres;M. Alcaráz;A. Pellicer
背景：阴道原发性非霍奇金淋巴瘤(NHL)是一种罕见的肿瘤。它与爱泼斯坦-巴尔病毒(EBV)的关联只在另一例病例中被报道。我们提出一个新的病例，强调EBV.CASE报告的致癌相关性。报告一位45岁的女性，在她的阴道检查中发现盆腔疼痛，有一种“铺路石”的外观，又厚又硬的阴道塞子。活检报告了一例阴道B型中间细胞非霍奇金淋巴瘤，EBV阳性。结论EBV是非霍奇金淋巴瘤的主要致癌物，被归类为I类致癌物，与多种肿瘤有关，但在结外B型弥漫性淋巴瘤中并不常见。
BACKGROUNDPrimary non-Hodgkin lymphoma (NHL) of the vagina is a rare location. Its association with the Epstein-Barr virus (EBV) has been only reported in another case. We present a new case, emphasizing the oncogenetic relevance of EBV.CASE REPORTA 45-year-old woman with a pelvic pain revealed in her vaginal inspection a thick and hard vaginal plug with a “paving stone” appearance. The biopsy reported a vaginal non-Hodgkin lymphoma type B of intermediate cell, with positive result for EBV. After treatment, a complete remission was obtained.CONCLUSIONThe EBV is the main responsible for the non-Hodgkin lymphoma; classified as a group I carcinogen, it has been associated with a variety of neoplastic tumors, although it is unusual with extranodal type B diffuse lymphoma.