Anxiety and depression in adult patients with celiac disease on a gluten-free diet
Anxiety and depression in adult patients with celiac disease on a gluten-free diet
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DOI：
10.3748/wjg.v16.i22.2780
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发表时间：
2010-06-14
影响因子：
4.3
通讯作者：
Hinz, Andreas
中科院分区：
文献类型：
--
作者：
Haeuser, Winfried;Janke, Karl-Heinz;Hinz, Andreas
目的：比较无麸质饮食(GFD)的成年乳糜泻(CD)患者和对照组的焦虑和抑郁水平。方法：采用医院焦虑和抑郁量表对441例成年CD患者的焦虑、抑郁水平和可能的焦虑或抑郁障碍进行评估，其中235例年龄和性别匹配的炎症性肠病(IBD)缓解期或轻度疾病活动患者，以及441名具有代表性的德国普通人群样本(GP)的成年人。结果：女性(P=0.01)预测CD患者的焦虑和抑郁程度(R2=0.07)。女性(OR=3.6，95%CI：1.3~9.4，P=0.01)与可能的焦虑症有关。独居(OR=0.5，95%CI：0.2-0.9，P=0.05)与患焦虑症的风险降低有关。测试的任何人口统计学和医学变量都不能预测抑郁症的水平和可能的抑郁障碍。CD组(6.6+/-3.4)和IBD组(6.9+/-3.7)焦虑水平明显高于GP组(4.6+/-3.3)(P均<0.001)。CD组(4.2+/-3.4)、IBD组(4.6+/-3.4)和GP组(4.2+/-3.8)的抑郁程度差异无统计学意义(P=0.3)。CD患者(16.8%)和IBD患者(14.0%)的焦虑症患病率高于全科医生(5.7%)(P<；0.001)。三组间可能存在抑郁障碍的患病率无显著差异(P=0.1)。结论：成年德国女性独身者在GFD上的焦虑感高于全科医生。服用GFD的女性独身者应该进行焦虑症筛查。(C)2010年白石登。版权所有。
AIM: To compare anxiety and depression levels in adult patients with celiac disease (CD) on a gluten-free diet (GFD) with controls.METHODS: The levels of anxiety, depression and of a probable anxiety or depressive disorder were assessed by the Hospital Anxiety and Depression Scale in 441 adult patients with CD recruited by the German Celiac Society, in 235 age- and sex-matched patients with inflammatory bowel disease (IBD) in remission or with slight disease activity, and in 441 adult persons of a representative German general population sample (GP). Potential demographic (age, sex, social class, family status) and disease-related (latency to diagnosis, duration of GFD, compliance with GFD, thyroid disease) predictors of anxiety and depression in CD were tested for by regression analyses.RESULTS: The level of anxiety in CD patients was predicted (R(2) = 0.07) by female gender (P = 0.01). Female sex (OR = 3.6, 95% CI: 1.3-9.4, P = 0.01) was associated with a probable anxiety disorder. Living alone (OR = 0.5, 95% CI: 0.2-0.9, P = 0.05) was associated with a reduced risk of an anxiety disorder. The level of depression and a probable depressive disorder were not predicted by any of the demographic and medical variables tested for. The levels of anxiety in patients with CD (6.6 +/- 3.4) and with IBD (6.9 +/- 3.7) were higher than those of persons in the GP (4.6 +/- 3.3) (both P < 0.001). The levels of depression in persons with CD (4.2 +/- 3.4), IBD (4.6 +/- 3.4) and of the GP (4.2 +/- 3.8) did not differ (P = 0.3). The prevalence of a probable anxiety disorder in persons with CD (16.8%) and IBD (14.0%) was higher than that of the GP (5.7%) (P < 0.001). The prevalence of a probable depressive disorder did not differ significantly between the three groups (P = 0.1).CONCLUSION: Anxiety in adult German female celiacs on a GFD is higher than in persons of the GP. Female celiacs on a GFD should be screened for anxiety. (C) 2010 Baishideng. All rights reserved.