Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats
Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats
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DOI：
10.1097/00008877-200107000-00005
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发表时间：
2001-07-01
影响因子：
1.6
通讯作者：
Bardo, MT
中科院分区：
文献类型：
--
作者：
Klebaur, JE;Bevins, RA;Bardo, MT
以前的工作已经表明，在不可避免的新环境中，运动活动的个体差异可以预测苯丙胺自我给药的获得。目前的研究调查了在自由选择测试中对新颖性的方法的个体差异是否也可以预测苯丙胺的自我给药。此外，目前的研究检查了在自由选择或不可避免的新颖性测试中的个体差异是否可以预测在存在和不存在苯丙胺的情况下对非药物增强剂(蔗糖)的反应。首先测试雄性和雌性大鼠对自由选择新颖性(操场迷宫和新颖性诱导的位置偏好测试)和不可避免的新颖性的反应。然后对他们进行蔗糖强化反应的获取、苯丙胺诱导的蔗糖强化反应维持的变化以及苯丙胺自我给药的测试。根据不可避免的新颖性测试，与低反应者(LR)相比，高反应者(HR)获得蔗糖强化反应的速度更快。这种对男性的影响并不适用于女性。这些新颖性测试都没有预测安非他明降低蔗糖维持反应的能力。然而，使用不可避免的新颖性测试，在测试的剂量范围内(0.03-0.16 mg/kg/次输液)，男性和女性HR自我注射的苯丙胺比LRs多。操场迷宫和新奇诱导的位置偏爱测试都不能预测苯丙胺的自我给药。这些结果表明，对自由选择的新颖性和不可避免的新颖性的反应预测了苯丙胺诱导行为的不同成分。(C)2001年，Lippincott Williams&Wilkins。
Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty, (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then tested for acquisition of sucrose-reinforced responding, am phetamine-induced changes in maintenance of sucrose-reinforced responding, and amphetamine self-administration. Based on the inescapable novelty test, acquisition of sucrose-reinforced responding was more rapid in male high responders (HR) compared to low responders (LR). This effect in males did not generalize to females. None of the novelty tests predicted the ability of amphetamine to decrease sucrose-maintained responding. However, using the inescapable novelty test, both male and female HRs self-administered more amphetamine than LRs within the dose range tested (0.03-0.16 mg/kg/infusion). Neither the playground maze nor the novelty-induced place preference test predicted amphetamine self-administration. These results indicate that responses to free choice novelty and inescapable novelty predict different components of amphetamine-induced behavior. (C) 2001 Lippincott Williams & Wilkins.