Bupropion increases cerebral activation in auditory affective processing: A randomized controlled fMRI study
Bupropion increases cerebral activation in auditory affective processing: A randomized controlled fMRI study
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DOI：
10.1016/j.neulet.2021.135716
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发表时间：
2021-02-24
影响因子：
2.5
通讯作者：
Okubo, Yoshiro
中科院分区：
文献类型：
--
作者：
Hama, Tomoko;Koeda, Michihiko;Okubo, Yoshiro
前言：安非他酮是一种抗抑郁药，副作用较小，不会引起情绪迟钝，在抑郁状态下也能提高消极的自我认知。以前的神经成像研究表明，作为抗抑郁药物的效果，面部表情会改变大脑功能。除了面部表情，声音情感加工对于准确识别他人的感受也是必不可少的，但据我们所知，还没有研究安非他酮是否影响听觉情感加工识别的大脑功能。本研究旨在探讨安非他酮对发声情绪反应的急性影响。方法：健康志愿者16人，男8人。通过随机安慰剂对照的受试者内试验，检查了使用安慰剂或安非他酮(150毫克)的两个系列的fMRI扫描。在fMRI扫描过程中执行听觉情绪配价判断任务。结果：与安慰剂相比，安非他酮能显著激活左侧脑岛和右侧颞叶上回的情绪声音，而杏仁核未被激活。使用安非他酮后，正性情绪回路在颞叶上回和额叶中回的激活程度显著增加。在行为表现方面，安慰剂和安非他明之间无显著差异。结论：安非他酮可增强大脑对情绪加工的反应，尤其是积极的情绪发声，提示安非他酮对抑郁症患者的治疗作用可能存在机制。
Introduction: Bupropion is an antidepressant with less possibility to give rise to emotional blunting as side effect, and it also acts on improving negative self-recognition in a depressive state. Previous neuroimaging studies indicated a change in brain function by facial expression as an effect of antidepressants. As well as facial expression, vocal affective processing is essential for accurately recognizing another's feelings, but to our knowledge, no study has investigated whether bupropion affects the cerebral function of recognition of auditory affective processing. In this study, we aimed to investigate the acute effect of bupropion on cerebral response to vocal affective processing.Methods: Sixteen healthy volunteers (male = 8) participated in this study. With a randomized placebo-controlled within-subject trial, two series of fMRI scans, using either placebo or bupropion (150 mg), were examined. An auditory emotional valence judgement task was performed during fMRI scanning. The acute effects of bupropion on cerebral activation in the emotional circuit and behavioral performance during emotional processing were analyzed.Results: Compared with placebo, bupropion caused a significantly greater activation of emotional voices in the left insula and right superior temporal gyrus, whereas the amygdala was not activated. By bupropion, a significantly greater activation of the positive emotional circuit was observed at the superior temporal gyrus and middle frontal gyrus. As for behavioral performance, no significant difference was observed between placebo and bupropion.Conclusions: Our findings suggest that bupropion enhances the cerebral response to affective processing, especially positive emotional vocalizations, indicating a possible mechanism underlying the therapeutic effects for patients with depression.