Selenium supplementation and blood rheological improvement in Japanese adults
Selenium supplementation and blood rheological improvement in Japanese adults
复制标题
DOI：
10.1385/bter:112:1:87
复制
发表时间：
2006-07-01
影响因子：
3.9
通讯作者：
Murakami, Masami
中科院分区：
文献类型：
--
作者：
Abdulah, Rizky;Koyama, Hiroshi;Murakami, Masami
为了研究硒对心血管疾病发展的预防作用，我们研究了补硒对血液流变学特性的影响。 11 名健康成年人每天服用 200 微克硒酵母形式的硒，持续 1 周。补充前后测定受试者血清硒浓度、谷胱甘肽过氧化物酶（GPx）活性、生化指标和血液流动性。使用(微通道阵列流动分析仪)通过100μL肝素化全血通过微通道阵列的通过时间来测量血液流动性。补硒显着 (p = .0.001) 将平均血液通过时间从 44.0 +/- 5.7 秒缩短至 37.5 +/- 2.8 秒。血清硒浓度显着（p = 0.008）从 109.8 +/- 10.2 增加到 124.5 +/- 16.7 mu g/L。同时，GPx 活性没有显着增加（p = 0.058）。补充前受试者的平均 GPx 活性为 171.0 +/- 16.1 Delta mmol NADPH/min/L，补充后为 180.9 +/- 17.8 Delta mmol NADPH/min/L。对受试者的通过时间和生化指标进行因子分析表明，补硒过程中血液流动性的改善与脂蛋白的代谢改变有关。这些结果表明，补充硒改善了血液流动性，但没有增加受试者的 GPx 活性。
In order to study the prevention effect of selenium in the development of cardiovascular disease, we investigated the effects of selenium supplementation on the blood rheological properties. Eleven healthy adults were administered with 200 mu g of selenium in the form of selenium yeast per day for 1 wk. Before and after the supplementation, serum selenium concentration, glutathione peroxidase (GPx) activity, biochemical indices, and the blood fluidity of the subjects were measured. The blood fluidity was measured using a (microchannel array flow analyzer) by the passage time of 100 mu L of heparinized whole blood through the microchannel array. The selenium supplementation significantly (p = .0.001) shortened the mean blood passage time from 44.0 +/- 5.7 to 37.5 +/- 2.8 s. Serum selenium concentration significantly (p = 0.008) increased from 109.8 +/- 10.2 to 124.5 +/- 16.7 mu g/L. Meanwhile, the GPx activity did not increased significantly (p = 0.058). The mean GPx activity of the subjects before supplementation was 171.0 +/- 16.1 Delta mmol NADPH/min/L and 180.9 +/- 17.8 Delta mmol NADPH/min/L after supplementation. Factor analysis of the passage time and biochemical indices of the subjects showed that blood fluidity improvement was related to the metabolic modification of lipoproteins during the selenium supplementation. These results showed that selenium supplementation improved the blood fluidity, without increasing the GPx activity of the subjects.